{{Rsnum
|rsid=2287987
|Gene=ERAP1
|Chromosome=5
|position=96793832
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.1304
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ERAP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 5.4 | 35.1 | 59.5
| HCB | 0.0 | 13.9 | 86.1
| JPT | 0.0 | 14.2 | 85.8
| YRI | 0.7 | 12.2 | 87.1
| ASW | 0.0 | 17.5 | 82.5
| CHB | 0.0 | 13.9 | 86.1
| CHD | 0.0 | 10.1 | 89.9
| GIH | 0.0 | 12.9 | 87.1
| LWK | 0.0 | 6.4 | 93.6
| MEX | 0.0 | 13.8 | 86.2
| MKK | 0.6 | 12.2 | 87.2
| TSI | 1.0 | 34.3 | 64.7
| HapMapRevision=28
}}
[[rs2287987]] is one of several SNPs in the [[ERAP1]] gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with [[ankylosing spondylitis]]. The odds ratio is 0.71 (p=1.0x10e-8).[PMID 17952073, PMID 18037607]

{{PMID Auto
|PMID=20032103
|Title=Association of ARTS1 Gene Polymorphisms with Ankylosing Spondylitis in the Hungarian Population: The rs27044 Variant Is Associated with HLA-B*2705 Subtype in Hungarian Patients with Ankylosing Spondylitis
}}

{{PMID Auto
|PMID=19414429
|Title=ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans
}}

{{PMID Auto
|PMID=21229357
|Title=The association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls
}}

{{PMID Auto
|PMID=19692350
|Title=Investigating the genetic association between ERAP1 and ankylosing spondylitis.
|OA=1
}}

{{PMID Auto
|PMID=21865284
|Title=ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population.
}}

{{PMID Auto
|PMID=21877190
|Title=Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
}}

{{PMID Auto
|PMID=22896742
|Title=Investigating the genetic association between ERAP1 and spondyloarthritis
}}

{{GET Evidence
|gene=ERAP1
|aa_change=Met349Val
|aa_change_short=M349V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2287987
|overall_frequency_n=1889
|overall_frequency_d=10758
|overall_frequency=0.17559
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.057
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}