{{Rsnum
|rsid=2288774
|Gene=NEDD4L
|Chromosome=18
|position=58316098
|Orientation=plus
|GMAF=0.4784
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NEDD4L
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 19.5 | 59.3 | 21.2
| HCB | 14.0 | 49.3 | 36.8
| JPT | 12.4 | 50.4 | 37.2
| YRI | 43.5 | 44.2 | 12.2
| ASW | 36.8 | 47.4 | 15.8
| CHB | 14.0 | 49.3 | 36.8
| CHD | 19.3 | 40.4 | 40.4
| GIH | 24.8 | 46.5 | 28.7
| LWK | 64.5 | 30.9 | 4.5
| MEX | 19.0 | 51.7 | 29.3
| MKK | 66.7 | 30.8 | 2.6
| TSI | 28.4 | 40.2 | 31.4
| HapMapRevision=28
}}[[rs2288774]] has been associated with [[hypertension]]. In genotypic combination with [[rs4149601]] it was associated with systolic blood pressure (SBP) (p=0.01), DBP (p=0.04), and progression of both SBP (p=0.03) and DBP (p=0.05) over time.{{PMID|16788695}}

{{PMID Auto
|PMID=20003179
|Title=Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study
|OA=1
}}

{{PMID|17044734|OA=1
}} European population substructure: clustering of northern and southern populations.

{{PMID|17487281|OA=1
}} Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP.

{{PMID Auto
|PMID=23549273
|Title=A Functional Variant of NEDD4L Is Associated with Obesity and Related Phenotypes in a Han Population of Southern China.
|OA=1
}}

{{PMID Auto
|PMID=24446284
|Title=Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}