{{Rsnum
|rsid=2293275
|Gene=LHCGR
|Chromosome=2
|position=48694236
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3655
|Gene_s=LHCGR,STON1-GTF2A1L
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.1 | 45.9 | 36.9
| HCB | 0.7 | 10.9 | 88.3
| JPT | 0.0 | 12.4 | 87.6
| YRI | 51.0 | 43.5 | 5.4
| ASW | 45.6 | 43.9 | 10.5
| CHB | 0.7 | 10.9 | 88.3
| CHD | 0.9 | 10.2 | 88.9
| GIH | 6.9 | 49.5 | 43.6
| LWK | 60.0 | 33.6 | 6.4
| MEX | 8.8 | 35.1 | 56.1
| MKK | 46.2 | 42.3 | 11.5
| TSI | 13.7 | 44.1 | 42.2
| HapMapRevision=28
}}SNP in the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) gene, correlated to spermatogenetic damage and thus a risk factor for [[male infertility]].{{PMID|18300940}}

{{PMID|17709176}} Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer.

{{PMID|18439297|OA=1
}} A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele.

{{PMID|19403562}} Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome.

{{GET Evidence
|gene=LHCGR
|aa_change=Asn312Ser
|aa_change_short=N312S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2293275
|overall_frequency_n=5268
|overall_frequency_d=10746
|overall_frequency=0.490229
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=67
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=0
|autoscore=2
|n_web_uneval=3
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}