{{Rsnum
|rsid=2293347
|Gene=EGFR
|Chromosome=7
|position=55201223
|Orientation=minus
|ReferenceAllele=C
|GMAF=0.135
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=EGFR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 17.7 | 81.4
| HCB | 9.5 | 39.4 | 51.1
| JPT | 11.5 | 43.4 | 45.1
| YRI | 0.0 | 0.7 | 99.3
| ASW | 0.0 | 3.5 | 96.5
| CHB | 9.5 | 39.4 | 51.1
| CHD | 5.5 | 41.3 | 53.2
| GIH | 6.9 | 33.7 | 59.4
| LWK | 0.0 | 0.0 | 0.0
| MEX | 1.7 | 24.1 | 74.1
| MKK | 0.0 | 3.2 | 96.8
| TSI | 2.0 | 6.9 | 91.2
| HapMapRevision=28
}}
[[rs2293347]], also known as D994D, is a SNP in the epidermal growth factor receptor [[EGFR]] gene.

In a study of therapeutic outcome and survival in 84 advanced [[non-small-cell lung cancer]] (NSCLC) patients treated with [[Gefitinib]], the response rate for [[rs2293347]](G;G) patients was almost double that of other genotypes for this SNP (71.2% versus 37.5%, p=0.0043). The [[rs2293347]](G;G) genotype was also associated with longer progression-free survival compared with the [[rs2293347]](A;G) or (A;A) genotypes (11 months versus 3 months, p=0.0018).{{PMID|19201048}}

{{PMID Auto
|PMID=17956637
|Title=Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19190167
|Title=A two-stage case-control study of EGFR polymorphisms and breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19372140
|Title=EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis.
|OA=1
}}

{{PMID Auto
|PMID=19641380
|Title=Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans.
|OA=1
}}

{{PMID Auto
|PMID=21859544
|Title=[Effect of rs2293347 Polymorphism in EGFR on the Clinical Efficacy of Gefitinib in Patients with Non-small Cell Lung Cancer].
}}

{{PMID Auto
|PMID=22552271
|Title=Integrated effect of EGFR and PAR-1 signaling crosstalk on airway hyperresponsiveness
}}

{{PMID Auto
|PMID=23313300
|Title=Role of EGFR SNPs in survival of advanced lung adenocarcinoma patients treated with Gefitinib.
}}

{{PMID Auto
|PMID=23816762
|Title=Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}