{{Rsnum
|rsid=2293870
|Gene=HTRA1
|Chromosome=10
|position=122461760
|Orientation=plus
|ReferenceAllele=G
|GMAF=0.2842
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=HTRA1
}}{{PMID|18164066}} [[rs2293870]] showed as strong an association with increased susceptibility to neovascular [[age related macular degeneration]] as the haplotypes containing [[rs10490924]] and [[rs11200638]].

{{PMID|18207215}} [[rs2293870]] and [[rs11200638]] are among the most significantly associated [[HTRA1]] SNPs with [[age related macular degeneration]].

{{ neighbor
| rsid = 11200638
| distance = 732
}}
{{ neighbor
| rsid = 1049331
| distance = 6
}}
{{PMID Auto
|PMID=19796758
|Title=Comprehensive Analysis of Complement Factor H and LOC387715/ARMS2/HTRA1 Variants with Respect to Phenotype in Advanced Age-related Macular Degeneration
|OA=1
}}{{ClinVar
|rsid=2293870
|Reversed=0
|FwdREF=G
|FwdALT=C,T
|REF=G
|ALT=C,T
|RSPOS=124221276
|CHROM=10
|GMAF=0.2843
|dbSNPBuildID=100
|SSR=0
|SAO=0
|VP=0x050168000000140116100100
|GENEINFO=HTRA1:5654
|GENE_NAME=HTRA1
|GENE_ID=5654
|WGT=0
|VC=SNV
|CLNALLE=1; 2
|CLNHGVS=NC_000010.10:g.124221276G>C; NC_000010.10:g.124221276G>T
|CLNSRC=GeneReviews
|CLNSRCID=NBK32533
|CLNSIG=2
|CLNCUI=C1838577
|CLNDBN=Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
|Disease=Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
|CLNACC=RCV000020490.1; RCV000020491.1
|Tags=PM;PMC;SLO;VLD;GNO;KGPhase1;KGPROD;OTHERKG;LSD
|CAF=0.7158; 0.2842
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK32533:C1838577:600142:199354
|COMMON=1
}}{{PMID Auto
|PMID=18316707
|Title=HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH.
|OA=1
}}

{{PMID Auto
|PMID=19026761
|Title=Molecular pathology of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=20140183
|Title=Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.
|OA=1
}}
{{PMID Auto
|PMID=23644223
|Title=Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina
}}