{{Rsnum
|rsid=2294008
|Gene=PSCA
|Chromosome=8
|position=142680513
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.432
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PSCA
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 32.7 | 50.4 | 16.8
| HCB | 48.5 | 44.1 | 7.4
| JPT | 14.2 | 53.1 | 32.7
| YRI | 58.2 | 34.9 | 6.8
| ASW | 26.3 | 54.4 | 19.3
| CHB | 48.5 | 44.1 | 7.4
| CHD | 44.9 | 46.7 | 8.4
| GIH | 23.8 | 53.5 | 22.8
| LWK | 31.8 | 50.9 | 17.3
| MEX | 19.0 | 50.0 | 31.0
| MKK | 31.0 | 38.7 | 30.3
| TSI | 32.4 | 52.0 | 15.7
| HapMapRevision=28
}}

{{PMID|18488030}} [[rs2976392]] and diffuse-type [[gastric cancer]] (allele-specific odds ratio (OR) = 1.62, 95% CI = 1.38-1.89, P = 1.11 x 10(-9)). Substitution of the C allele with the risk allele T at a SNP in the first exon ([[rs2294008]], which has r(2) = 0.995, D' = 0.999 with rs2976392) reduces transcriptional activity of an upstream fragment of the gene

{{omim
|desc=GASTRIC CANCER
|id=137215
|rsnum=2294008
}}

{{omim
|desc=PROSTATE STEM CELL ANTIGEN; PSCA
|id=602470
|rsnum=2294008
}}
{{PMID Auto GWAS
|PMID=19648920
|Trait=Bladder cancer
|Title=Genetic variation in the prostate stem cell antigen gene
PSCA confers susceptibility to urinary bladder cancer
|RiskAllele=T
|Pval=2E-10
|OR=1.15
|ORtxt=[1.10-1.20]
|OA=1
}}

{{PMID Auto
|PMID=20083643
|Title=Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population
}}

{{PMID Auto
|PMID=20131315
|Title=Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-gastric cancer in a Chinese population
}}

{{PMID Auto
|PMID=21064099
|Title=Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population
}}
{{PMID Auto
|PMID=21070779
|Title=A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Short title: MUC1is a gastric cancer susceptibility gene
}}
{{PMID Auto
|PMID=21070776
|Title=An association between a variation in the PSCA gene and upper gastrointestinal cancer in Caucasians
|OA=1
}}
{{PMID Auto GWAS
|PMID=20972438
|Trait=None
|Title=A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
|RiskAllele=T
|Pval=4E-11
|OR=1.1300
|ORtxt=[1.09-1.17]
|OA=1
}}

{{PMID Auto
|PMID=21268123
|Title=Polymorphisms in prostate stem cell antigen gene rs2294008 increase gastric cancer risk in Chinese
}}

{{PMID Auto
|PMID=21681742
|Title=Prostate stem cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: Results from the EPIC-EURGAST Study
}}

{{PMID Auto
|PMID=22416122
|Title=Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
|OA=1
}}

{{PMID Auto
|PMID=22481254
|Title=The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis
}}

{{PMID Auto
|PMID=22387998
|Title=A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population
}}

{{PMID Auto
|PMID=22768238
|Title=A MicroRNA-7 Binding Site Polymorphism in HOXB5 Leads to Differential Gene Expression in Bladder Cancer
|OA=1
}}

{{PMID Auto
|PMID=22824379
|Title=Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study
|OA=1
}}

{{PMID Auto
|PMID=19554573
|Title=Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a Chinese population.
}}

{{PMID Auto
|PMID=19582881
|Title=Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese.
}}

{{PMID Auto
|PMID=20230293
|Title=Association and haplotype analysis of prostate stem cell antigen with gastric cancer in Tibetans.
}}

{{PMID Auto
|PMID=21538581
|Title=Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a Korean population.
}}

{{PMID Auto
|PMID=22037551
|Title=A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
}}

{{PMID Auto
|PMID=22426141
|Title=Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis.
}}

{{GET Evidence
|gene=PSCA
|aa_change=Thr1Met
|aa_change_short=T1M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2294008
|overall_frequency_n=4182
|overall_frequency_d=10002
|overall_frequency=0.418116
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|nblosum100=2
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23266392
|Title=Genetic Variant as a Selection Marker for Anti-Prostate Stem Cell Antigen Immunotherapy of Bladder Cancer
|OA=1
}}

{{PMID Auto
|PMID=23330817
|Title=Evolution of the concept of androgen-sensitive bladder cancer
}}

{{PMID Auto
|PMID=23397433
|Title=Gender-specific differences in muscle-invasive bladder cancer: the concept of sex steroid sensitivity
}}

{{PMID Auto
|PMID=22938426
|Title=Case-control study of single nucleotide polymorphisms of PSCA and MUC1 genes with gastric cancer in a Chinese
}}

{{PMID Auto
|PMID=23599686
|Title=Missense allele of a single nucleotide polymorphism rs2294008 attenuated antitumor effects of prostate stem cell antigen in gallbladder cancer cells
|OA=1
}}

{{PMID Auto
|PMID=23704932
|Title=Impact of PSCA Variation on Gastric Ulcer Susceptibility
|OA=1
}}

{{PMID Auto
|PMID=23967685
|Title=[Possible role of genetic factors on reduced risk for gastric cancer among duodenal ulcer patients]
}}

{{PMID Auto
|PMID=23988503
|Title=PSCA Gene Variants (rs2294008 and rs2978974) Confer Increased Susceptibility of Gallbladder Carcinoma in Females
}}

{{PMID Auto
|PMID=24023815
|Title=Genetic Variation in PSCA and Risk of Gastric Advanced Preneoplastic Lesions and Cancer in Relation to Helicobacter pylori Infection
|OA=1
}}

{{PMID Auto
|PMID=22711262
|Title=Systematic evaluation of bladder cancer risk-associated single-nucleotide polymorphisms in a Chinese population.
}}

{{PMID Auto
|PMID=23397970
|Title=Interpersonal and genetic origins of adult attachment styles: a longitudinal study from infancy to early adulthood.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=24163127
  |Trait=Bladder cancer
  |Title=Genome-wide association study identifies multiple loci associated with bladder cancer risk.
  |RiskAllele=T
  |Pval=3E-15
  |OR=1.13
  |ORtxt=[1.10-1.16]
  }}

{{PMID Auto
|PMID=25097570
|Title=Association of a common genetic variant in prostate stem cell antigen with cancer risk
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}