{{Rsnum
|rsid=2295190
|Gene=SYNE1
|Chromosome=6
|position=152122609
|Orientation=plus
|GMAF=0.09275
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=SYNE1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 70.8 | 24.6 | 4.6
| HCB | 91.1 | 6.7 | 2.2
| JPT | 68.9 | 31.1 | 0.0
| YRI | 98.4 | 1.6 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 91.1 | 6.7 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs2295190]] is a SNP in the spectrin repeat containing, nuclear envelope 1 [[SYNE1]] gene, located 19kb downstream of the estrogen receptor alpha ESR1 gene.

A large study (over 5,000 cases) of [[ovarian cancer]] samples from the Ovarian Cancer Association Consortium concluded that carriers of a [[rs2295190]](T) allele are at slightly increased risk for [[ovarian cancer]] (odds ratio 1.09, CI: 1.02-1.17, p=0.017).{{PMID|20056644|OA=1
}}

{{GET Evidence
|gene=SYNE1
|aa_change=Leu8741Met
|aa_change_short=L8741M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2295190
|overall_frequency_n=1116
|overall_frequency_d=10758
|overall_frequency=0.103737
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.088
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-3
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}