{{Rsnum
|rsid=2297508
|Gene=SREBF1
|Chromosome=17
|position=17812003
|Orientation=minus
|GMAF=0.4578
|Gene_s=LOC100289553,SREBF1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 58.5 | 32.3 | 9.2
| HCB | 6.7 | 22.2 | 71.1
| JPT | 0.0 | 31.8 | 68.2
| YRI | 54.0 | 33.3 | 12.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 6.7 | 22.2 | 71.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs2297508]] is one of several SNPs associated with the [[SREBF1]] gene that show a modest association with [[type-2 diabetes]].

A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.17 (CI: 1.05-1.30, p=0.003) for the minor (risk) allele, [[rs2297508]](C). A meta-analysis included other published studies concluded the odds ratio was 1.08 (CI: 1.03-1.14, p=0.001).{{PMID|18192539}}

{{PMID|18692268}} [[type-2 diabetes]] [[rs2297508]](C) and [[rs11868035]](C)

{{ neighbor
| rsid = 11868035
| distance = 216
}}

{{PMID Auto
|PMID=21178094
|Title=A Two-Step Association Study Identifies CAV2 rs2270188 Single Nucleotide Polymorphism Interaction with Fat Intake in Type 2 Diabetes Risk
}}

{{PMID Auto
|PMID=21609284
|Title=Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth
}}

{{PMID Auto
|PMID=22678801
|Title=[Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population]
}}
{{PMID Auto
|PMID=17160088
|Title=The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population.
}}

{{PMID Auto
|PMID=24152445
|Title=Identification of Combined Genetic Determinants of Liver Stiffness within the SREBP1c-PNPLA3 Pathway
|OA=1
}}

{{PMID Auto
|PMID=24614076
|Title=Single Nucleotide Polymorphism of SREBF-1 Gene Associated with an Increased Risk of Endometrial Cancer in Chinese Women
|OA=1
}}

{{on chip | HumanOmni1Quad}}