{{Rsnum
|rsid=2297518
|Gene=NOS2
|Chromosome=17
|position=27769571
|Orientation=plus
|GMAF=0.1726
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NOS2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 32.7 | 66.4
| HCB | 1.5 | 25.7 | 72.8
| JPT | 0.0 | 15.0 | 85.0
| YRI | 0.0 | 19.7 | 80.3
| ASW | 1.8 | 31.6 | 66.7
| CHB | 1.5 | 25.7 | 72.8
| CHD | 1.9 | 38.0 | 60.2
| GIH | 5.0 | 25.7 | 69.3
| LWK | 0.9 | 24.5 | 74.5
| MEX | 1.7 | 22.4 | 75.9
| MKK | 12.2 | 39.1 | 48.7
| TSI | 5.9 | 33.3 | 60.8
| HapMapRevision=28
}}{{PMID Auto
|PMID=20565800
|Title=Gastric cancer is associated with NOS2 -954G/C polymorphism and environmental factors in a Brazilian population
|OA=1
}}
{{PMID Auto
|PMID=20581851
|Title=Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD
}}

{{PMID Auto
|PMID=21716319
|Title=Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy
}}

{{PMID Auto
|PMID=21963893
|Title=Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population
}}

{{PMID Auto
|PMID=22234503
|Title=Inducible nitric oxide synthase haplotype associated with migraine and aura
}}

{{PMID|16543247}} Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma.

{{PMID|16642433|OA=1
}} Polymorphism in maternal LRP8 gene is associated with fetal growth.

{{PMID|17355643|OA=1
}} Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

{{PMID|17601350|OA=1
}} A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

{{PMID|17955236}} Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility.

{{PMID|18663495|OA=1
}} Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease.

{{PMID|18667089|OA=1
}} A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis.

{{PMID|18676870|OA=1
}} Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

{{PMID|19168583|OA=1
}} Nitric oxide synthase gene polymorphisms and prostate cancer risk.

{{PMID|19309520|OA=1
}} Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease.

{{PMID|20416077|OA=1
}} Identification of type 2 diabetes-associated combination of SNPs using support vector machine.

{{PMID|20562898|OA=1
}} Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia.

{{PMID|20811626|OA=1
}} Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

{{PMID|21385363|OA=1
}} Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

{{PMID|21481004}} Association between recurrent aphthous stomatitis and inheritance of a single-nucleotide polymorphism of the NOS2 gene encoding inducible nitric oxide synthase.

{{PMID|21612325}} Ser608Leu polymorphisms in the nitric oxide synthase-2 gene may influence urinary bladder cancer pathogenesis.

{{GET Evidence
|gene=NOS2
|aa_change=Ser608Leu
|aa_change_short=S608L
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2297518
|overall_frequency_n=1814
|overall_frequency_d=10758
|overall_frequency=0.168619
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=12
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.157
|nblosum100=6
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23192595
|Title=A non-synonymous SNP in the NOS2 associated with septic shock in patients with sepsis in Chinese populations
}}

{{PMID Auto
|PMID=23572278
|Title=Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans
}}

{{PMID Auto
|PMID=24114042
|Title=Nitric Oxide Synthase Gene Polymorphisms in Functional Dyspepsia
}}

{{PMID Auto
|PMID=24430113
|Title=Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease
|OA=1
}}

{{PMID Auto
|PMID=22865486
|Title=Interaction among nitric oxide (NO)-related genes in migraine susceptibility.
}}

{{PMID Auto
|PMID=24746566
|Title=Genetic variants in inducible nitric oxide synthase gene are associated with the risk of radiation-induced lung injury in lung cancer patients receiving definitive thoracic radiation
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}