{{Rsnum
|rsid=2297595
|Gene=DPYD
|Chromosome=1
|position=97699535
|Orientation=plus
|GMAF=0.06612
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DPYD
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 14.3 | 85.7
| HCB | 0.0 | 3.0 | 97.0
| JPT | 0.0 | 2.7 | 97.3
| YRI | 0.0 | 2.7 | 97.3
| ASW | 0.0 | 10.9 | 89.1
| CHB | 0.0 | 3.0 | 97.0
| CHD | 0.0 | 1.9 | 98.1
| GIH | 0.0 | 6.9 | 93.1
| LWK | 0.9 | 21.1 | 78.0
| MEX | 0.0 | 15.8 | 84.2
| MKK | 0.0 | 13.6 | 86.4
| TSI | 1.0 | 18.8 | 80.2
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2297595
|Name_s=DPYD:496A>G, DPYD:Met166Val
|Gene_s=DPYD
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19104657
|Annotation=The DPYD:496A>G variant was associated with toxicity of fluoropyrimidine-based chemotherapy in patients with gastroesophageal and breast cancer, but did not reach significance in patients with colorectal malignancies.
|Drugs=capecitabine; fluorouracil
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162372824
}}

{{GET Evidence
|gene=DPYD
|aa_change=Met166Val
|aa_change_short=M166V
|impact=pharmacogenetic
|qualified_impact=High clinical importance, Likely pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2297595
|overall_frequency_n=838
|overall_frequency_d=10758
|overall_frequency=0.0778955
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=12
|n_articles=3
|n_articles_annotated=3
|qualityscore_case_control=5
|qualitycomment_case_control=Y
|qualityscore_severity=3
|qualitycomment_severity=Y
|qualityscore_treatability=4
|qualitycomment_treatability=Y
|gene_in_genetests=Y
|in_pharmgkb=Y
|pph2_score=0.998
|genetests_testable=Y
|nblosum100=0
|max_or_disease_name=Hereditary Thymine-Uraciluria
|max_or_case_pos=22
|max_or_case_neg=7
|max_or_control_pos=70
|max_or_control_neg=82
|max_or_or=3.682
|autoscore=4
|webscore=N
|n_web_uneval=10
|variant_evidence=2
|clinical_importance=1
|summary_short=Associated with DPYD deficiency and poor prognosis for chemotherapy w/ 5-flurorouracil. 
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}