{{Rsnum
|rsid=2297660
|Gene=LRP8
|Chromosome=1
|position=53266643
|Orientation=minus
|GMAF=0.4017
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=LRP8
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 18.6 | 49.6 | 31.9
| HCB | 38.0 | 46.0 | 16.1
| JPT | 45.1 | 46.0 | 8.8
| YRI | 3.4 | 28.6 | 68.0
| ASW | 3.5 | 33.3 | 63.2
| CHB | 38.0 | 46.0 | 16.1
| CHD | 44.0 | 40.4 | 15.6
| GIH | 1.0 | 27.7 | 71.3
| LWK | 4.5 | 46.4 | 49.1
| MEX | 3.4 | 48.3 | 48.3
| MKK | 12.8 | 44.2 | 42.9
| TSI | 10.8 | 46.1 | 43.1
| HapMapRevision=28
}}

{{omim
|desc=LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; LRP8
|id=602600
|rsnum=2297660
}}

{{PharmGKB
|RSID=rs2297660
|Name_s=
|Gene_s=LRP8
|Feature=
|Evidence=PubMed ID:16642433
|Annotation=In a candidate gene study which was replicated in a larger independent sample, this SNP was the most significantly associated of three SNPs(which are in strong linkage disequilibrium) where the maternal genotype was associated with birth weight in babies of black women, especially if the women were preeclamptic.
|Drugs=
|Drug Classes=
|Diseases=Fetal Growth Retardation
|Curation Level=Curated
|PharmGKB Accession ID=PA161795938
}}

{{PMID Auto
|PMID=22419519
|Title=Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2297660
|overall_frequency_n=3713
|overall_frequency_d=10758
|overall_frequency=0.345138
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23524007
|Title=Multi-allelic haplotype association identifies novel information different from single-SNP analysis: a new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI.
|OA=1
}}

{{PMID Auto
|PMID=24867879
|Title=A Novel Molecular Diagnostic Marker for Familial and Early-Onset CAD and MI in the LRP8 Gene
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}