{{Rsnum
|rsid=2298668
|Gene=PRCP
|Chromosome=11
|position=82853252
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=C
|GMAF=0.1383
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Status=Merged
|Merged=2229437
|Gene_s=PRCP
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 81.5 | 16.9 | 1.5
| HCB | 88.9 | 11.1 | 0.0
| JPT | 90.9 | 9.1 | 0.0
| YRI | 85.7 | 14.3 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 88.9 | 11.1 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

Women with the snp has been linked to significant risk of a [[premature birth]] {{PMID|16681991}}

These [http://www.eurekalert.org/pub_releases/2006-08/vcu-gvi081606.php press] [http://www.eurekalert.org/pub_releases/2006-08/modb-rdg081706.php releases] explain it more simply

The risky variation is 3x more common in women of african descent.

*[[rs2298668]] Prolylcarboxypepdiase E112D (rs2298668)D allele alone and jointly with chronic hypertension were associated with a significantly increased risk of preeclampsia

{{PMID|16642433|OA=1
}} Polymorphism in maternal LRP8 gene is associated with fetal growth.

{{GET Evidence
|gene=PRCP
|aa_change=Glu112Asp
|aa_change_short=E112D
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2298668
|overall_frequency_n=1722
|overall_frequency_d=10758
|overall_frequency=0.160067
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.012
|nblosum100=-2
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}