{{Rsnum
|rsid=2300747
|Gene=CD58
|Chromosome=1
|position=116561593
|Orientation=plus
|GMAF=0.3113
|Gene_s=CD58,MIR548AC
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 76.1 | 21.2 | 2.7
| HCB | 20.4 | 46.0 | 33.6
| JPT | 14.2 | 31.9 | 54.0
| YRI | 57.8 | 34.7 | 7.5
| ASW | 50.9 | 43.9 | 5.3
| CHB | 20.4 | 46.0 | 33.6
| CHD | 19.3 | 48.6 | 32.1
| GIH | 52.5 | 37.6 | 9.9
| LWK | 45.9 | 40.4 | 13.8
| MEX | 53.4 | 37.9 | 8.6
| MKK | 35.3 | 43.6 | 21.2
| TSI | 72.5 | 25.5 | 2.0
| HapMapRevision=28
}}
{{PMID|19237575|OA=1
}} [[multiple sclerosis]] protective rs2300747(G)

{{PMID Auto GWAS
|PMID=19525953
|Trait=Multiple sclerosis
|Title=Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
|RiskAllele=A
|Pval=3E-10
|OR=1.30
|ORtxt=[1.14-1.47]
|OA=1
}}

{{omim
|id=126200
|rsnum=2300747
}}

{{PMID Auto GWAS
|PMID=22190364
|Trait=None
|Title=Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|RiskAllele=A
|Pval=6E-9
|OR=1.3700
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=20182566
|Title=The genetic aspects of multiple sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=20405052
|Title=The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2300747
|overall_frequency_n=33
|overall_frequency_d=128
|overall_frequency=0.257812
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24655566
|Title=CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}