{{Rsnum
|rsid=2301436
|Gene=FGFR1OP
|Chromosome=6
|position=167024500
|Orientation=minus
|GMAF=0.3875
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Increased risk for Crohn's disease
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FGFR1OP
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 25.7 | 39.8 | 34.5
| HCB | 12.4 | 54.0 | 33.6
| JPT | 12.4 | 47.8 | 39.8
| YRI | 10.2 | 52.4 | 37.4
| ASW | 17.5 | 40.4 | 42.1
| CHB | 12.4 | 54.0 | 33.6
| CHD | 15.6 | 42.2 | 42.2
| GIH | 14.9 | 44.6 | 40.6
| LWK | 7.3 | 40.9 | 51.8
| MEX | 22.4 | 34.5 | 43.1
| MKK | 9.6 | 50.0 | 40.4
| TSI | 23.5 | 52.9 | 23.5
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs2301436
|PubMedID=18587394
|Condition=Crohn's disease
|Gene=CCR6
|Risk Allele=T
|pValue=1.00E-012
|OR=1.21
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs2301436
|Name_s=
|Gene_s=FGFR1OP
|Feature=
|Evidence=PubMed ID:18587394; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease (Initial Sample Size: 3,230 cases 4,829 controls; Replication Sample Size: 2,325 cases 1,809 controls 1,339 affected trios; Risk Allele: rs2301436-T).
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356803
}}

{{PMID Auto GWAS
|PMID=20570966
|Trait=Crohn's disease
|Title=Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease
|RiskAllele=
|Pval=6E-8
|OR=1.37
|ORtxt=[1.22-1.53]
|OA=1
}}

DeCode reports that [[rs2301436]] is associated with susceptibility to [[Crohn's disease]]. {{PMID|18587394|OA=1
}}

{{PMID Auto
|PMID=22269120
|Title=Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease
}}

{{PMID Auto
|PMID=19557189
|Title=Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
|OA=1
}}

{{PMID Auto
|PMID=20018022
|Title=Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.
|OA=1
}}

{{PMID Auto
|PMID=21304891
|Title=A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=21763254
|Title=Polymorphisms in CCR6 are associated with chronic graft-versus-host disease and invasive fungal disease in matched-related hematopoietic stem cell transplantation.
}}

{{PMID Auto
|PMID=21873313
|Title=There is no association of CCR6 polymorphisms with susceptibility to Behcet's disease in two Chinese Han populations.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2301436
|overall_frequency_n=53
|overall_frequency_d=126
|overall_frequency=0.420635
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22922229
|Title=Seven newly identified loci for autoimmune thyroid disease.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}