{{Rsnum
|rsid=2302254
|Gene=NME1
|Chromosome=17
|position=51153539
|Orientation=plus
|GMAF=0.2479
|Gene_s=NME1,NME1-NME2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 65.5 | 32.7 | 1.8
| HCB | 56.6 | 35.3 | 8.1
| JPT | 56.6 | 36.3 | 7.1
| YRI | 42.2 | 46.3 | 11.6
| ASW | 50.9 | 40.4 | 8.8
| CHB | 56.6 | 35.3 | 8.1
| CHD | 50.5 | 42.2 | 7.3
| GIH | 89.1 | 8.9 | 2.0
| LWK | 31.8 | 48.2 | 20.0
| MEX | 73.7 | 22.8 | 3.5
| MKK | 57.7 | 37.8 | 4.5
| TSI | 64.4 | 32.7 | 3.0
| HapMapRevision=28
}}{{PMID|18676749|OA=1
}} [[breast cancer]] 1,134 breast cancer patients recruited as part of the Shanghai Breast Cancer Study who were followed for a median of 7.1 years. [[rs2302254]] was also associated with breast cancer (HR, 1.3; 95% CI, 1.0-1.6). strong linkage disequilibrium for [[rs16949646]] [[rs2302254]] and [[rs3760468]]

{{PMID|21824052}} [[Acute myeloid leukemia]] patients carrying [[rs2302254]](T) alleles are at much higher risk of developing neurotoxic side effects if treated with Ara-C ([[cytarabine]]), compared to those not carrying a (T) allele. 

{{ neighbor
| rsid = 3760468
| distance = 409
}}

{{PMID Auto
|PMID=20599259
|Title=Significant association of genetic polymorphism of human nonmetastatic clone 23 type 1 gene with an increased risk of endometrial cancer
}}

{{PMID Auto
|PMID=22035418
|Title=The T_T genotype within the NME1 promoter SNP -835 C/T is associated with an increased risk of Ara-C induced neurotoxicity in AML patients
}}

{{PMID Auto
|PMID=20601538
|Title=Polymorphisms of human nonmetastatic clone 23 type 1 gene and neoplastic lesions of uterine cervix.
}}

{{PMID Auto
|PMID=22683585
|Title=nm23 gene polymorphisms are associated with survival of patients with epithelial ovarian cancer but not with susceptibility to disease.
}}

{{PMID Auto
|PMID=22903495
|Title=Associations of non-metastatic cells 1 gene polymorphisms with lymph node metastasis risk of gastric cancer in Northern Chinese population.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}