{{Rsnum
|rsid=2302685
|Gene=LRP6
|Chromosome=12
|position=12148964
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1212
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=LRP6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.5 | 31.0 | 65.5
| HCB | 2.2 | 18.4 | 79.4
| JPT | 0.0 | 12.5 | 87.5
| YRI | 0.7 | 12.9 | 86.4
| ASW | 0.0 | 21.1 | 78.9
| CHB | 2.2 | 18.4 | 79.4
| CHD | 0.9 | 10.1 | 89.0
| GIH | 1.0 | 15.8 | 83.2
| LWK | 2.7 | 26.4 | 70.9
| MEX | 1.8 | 12.3 | 86.0
| MKK | 7.1 | 35.3 | 57.7
| TSI | 2.9 | 31.4 | 65.7
| HapMapRevision=28
}}

rs2302685 increases susceptibility to Alzheimer's disease, late-onset 1.30 times for carriers of the T allele {{PMID|17517621|OA=1
}}

{{PMID Auto
|PMID=22393312
|Title=Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease
|OA=1
}}

{{PMID Auto
|PMID=18340469
|Title=Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.
|OA=1
}}

{{PMID Auto
|PMID=19667113
|Title=A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol.
|OA=1
}}

{{PMID Auto
|PMID=20057906
|Title=Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma.
|OA=1
}}

{{PMID Auto
|PMID=20926594
|Title=Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.
}}

{{GET Evidence
|gene=LRP6
|aa_change=Val1062Ile
|aa_change_short=V1062I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2302685
|overall_frequency_n=9062
|overall_frequency_d=10758
|overall_frequency=0.84235
|n_genomes=56
|n_genomes_annotated=0
|n_haplomes=97
|n_articles=0
|n_articles_annotated=0
|nblosum100=-4
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24906453
|Title=The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}