{{Rsnum
|rsid=2303064
|Gene=SPINK5
|Chromosome=5
|position=148100517
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3021
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SPINK5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 1.8 | 16.8 | 81.4
| HCB | 21.9 | 48.2 | 29.9
| JPT | 16.8 | 55.8 | 27.4
| YRI | 29.3 | 51.0 | 19.7
| ASW | 26.3 | 49.1 | 24.6
| CHB | 21.9 | 48.2 | 29.9
| CHD | 19.3 | 46.8 | 33.9
| GIH | 12.9 | 46.5 | 40.6
| LWK | 23.6 | 49.1 | 27.3
| MEX | 5.3 | 19.3 | 75.4
| MKK | 14.7 | 51.3 | 34.0
| TSI | 1.0 | 29.0 | 70.0
| HapMapRevision=28
}}[[rs2303064]], a SNP in the [[SPINK5]] gene, has been associated with susceptibility to [[atopic dermatitis]]. {{PMID|11544479}}

{{ neighbor
| rsid = 2303067
| distance = 875
}}

{{ neighbor
| rsid = 2303063
| distance = 53
}}

{{PMID Auto
|PMID=16519819
|Title=Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=21087323
|Title=Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans.
}}

{{GET Evidence
|gene=SPINK5
|aa_change=Asp386Asn
|aa_change_short=D386N
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2303064
|overall_frequency_n=2264
|overall_frequency_d=10002
|overall_frequency=0.226355
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-1
|autoscore=2
|n_web_uneval=4
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}