{{Rsnum
|rsid=2303436
|Gene=DLAT
|Chromosome=11
|position=112025600
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.3792
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DLAT
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 7.1 | 40.7 | 52.2
| HCB | 35.0 | 55.5 | 9.5
| JPT | 37.2 | 50.4 | 12.4
| YRI | 5.4 | 28.6 | 66.0
| ASW | 5.3 | 29.8 | 64.9
| CHB | 35.0 | 55.5 | 9.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 9.9 | 50.5 | 39.6
| LWK | 11.0 | 43.1 | 45.9
| MEX | 12.1 | 44.8 | 43.1
| MKK | 12.3 | 44.8 | 42.9
| TSI | 7.9 | 46.5 | 45.5
| HapMapRevision=28
}}

{{Venter SNP
|rsid=2303436
|allele=T
|frequency=0.242
|uid=1103649792825
|type=heterozygous_SNP
|hugo=DLAT
|ensembl gene=ENSG00000150768
|ensembl transcript=ENST00000280346
|sift=TOLERATED
|disease=Primary biliary cirrhosis is a chronic, progressive cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients' serum. It manifests with inflammatory obliteration of intra-hepatic bile duct, leading to liver cell damage and cirrhosis. Patients with primary biliary cirrhosis show autoantobodies againts the E2 component of pyruvate dehydrogenase complex.
}}

{{GET Evidence
|gene=DLAT
|aa_change=Ala43Val
|aa_change_short=A43V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2303436
|overall_frequency_n=3286
|overall_frequency_d=10756
|overall_frequency=0.305504
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=2
|autoscore=2
|n_web_uneval=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}