{{Rsnum
|rsid=2304256
|Gene=TYK2
|Chromosome=19
|position=10364976
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.287
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=TYK2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 11.6 | 41.1 | 47.3
| HCB | 21.3 | 54.4 | 24.3
| JPT | 15.0 | 48.7 | 36.3
| YRI | 0.0 | 19.0 | 81.0
| ASW | 1.8 | 23.2 | 75.0
| CHB | 21.3 | 54.4 | 24.3
| CHD | 32.1 | 39.4 | 28.4
| GIH | 10.0 | 30.0 | 60.0
| LWK | 4.5 | 20.0 | 75.5
| MEX | 1.7 | 34.5 | 63.8
| MKK | 3.2 | 28.6 | 68.2
| TSI | 11.8 | 29.4 | 58.8
| HapMapRevision=28
}}[[rs2304256]] is a SNP in the [[TYK2]] gene on chromosome 19. The most common allele, [[rs2304256]](C), has been associated with increased risk for systemic [[lupus]] erythematosus ([[SLE]]), with an odds ratio of 1.6 (CI: 1.3-1.9).{{PMID|15657875|OA=1
}}

{{PMID|19440814}} No association was seen between this SNP and SLE in a study of 411 Japanese SLE patients.

{{PMID Auto
|PMID=19653082
|Title=Strong Evidence of a Combination Polymorphism of the Tyrosine Kinase 2 Gene and the Signal Transducer and Activator of Transcription 3 Gene as a DNA-Based Biomarker for Susceptibility to Crohn's Disease in the Japanese Population
|OA=1
}}
{{PMID Auto
|PMID=19714582
|Title=Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors
}}

{{PMID Auto GWAS
|PMID=19966805
|Trait=Type 1 diabetes
|Title=The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes
|RiskAllele=C
|Pval=4E-9
|OR=1.16
|ORtxt=[1.11-1.22]
|OA=1
}}

{{PMID Auto
|PMID=21140222
|Title=Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases
}}

{{PMID Auto GWAS
|PMID=21829393
|Trait=None
|Title=Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|RiskAllele=
|Pval=1E-10
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID|18270328|OA=1
}} Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

{{PMID|19442287|OA=1
}} Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.

{{PMID|19567624}} Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus.

{{PMID|19604093|OA=1
}} Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

{{PMID|19758313}} Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.

{{GET Evidence
|gene=TYK2
|aa_change=Val362Phe
|aa_change_short=V362F
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2304256
|overall_frequency_n=2421
|overall_frequency_d=10758
|overall_frequency=0.225042
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|pph2_score=0.003
|nblosum100=3
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22592861
|Title=Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.
}}

{{PMID Auto
|PMID=23000200
|Title=TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}