{{Rsnum
|rsid=2305160
|Gene=NPAS2
|Chromosome=2
|position=100974842
|Orientation=minus
|GMAF=0.2314
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=AC016738.3,NPAS2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 51.3 | 38.1 | 10.6
| HCB | 63.2 | 34.6 | 2.2
| JPT | 63.7 | 34.5 | 1.8
| YRI | 95.2 | 4.8 | 0.0
| ASW | 80.7 | 19.3 | 0.0
| CHB | 63.2 | 34.6 | 2.2
| CHD | 70.6 | 26.6 | 2.8
| GIH | 56.4 | 39.6 | 4.0
| LWK | 93.6 | 6.4 | 0.0
| MEX | 46.6 | 43.1 | 10.3
| MKK | 89.1 | 10.9 | 0.0
| TSI | 42.2 | 50.0 | 7.8
| HapMapRevision=28
}}{{PMID Auto
|PMID=21140207
|Title=A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk
}}

{{PMID|17096334|OA=1
}} Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma.

{{PMID|17984998}} Variants in circadian genes and prostate cancer risk: a population-based study in China.

{{PMID|18990770}} Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-I.

{{PMID|19470168|OA=1
}} NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.

{{PMID|20180986|OA=1
}} CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.

{{PMID|20368993|OA=1
}} ARNTL (BMAL1) and NPAS2 gene variants contribute to fertility and seasonality.

{{GET Evidence
|gene=NPAS2
|aa_change=Thr394Ala
|aa_change_short=T394A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2305160
|overall_frequency_n=8032
|overall_frequency_d=10758
|overall_frequency=0.746607
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=92
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24754267
|Title=Functional polymorphisms in NPAS2 gene are associated with overall survival in TACE-treated hepatocellular carcinoma patients
}}

{{PMID Auto
|PMID=25227809
|Title=Lack of Association of the NPAS2 Gene Ala394Thr Polymorphism (rs2305160:G&gt;A) with Risk of Chronic Lymphocytic Leukemia
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}