{{Rsnum
|rsid=2305480
|Gene=GSDMB
|Chromosome=17
|position=39905943
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.3283
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GSDMB
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 27.4 | 51.3 | 21.2
| HCB | 44.1 | 45.6 | 10.3
| JPT | 51.8 | 40.2 | 8.0
| YRI | 89.7 | 9.6 | 0.7
| ASW | 57.9 | 35.1 | 7.0
| CHB | 44.1 | 45.6 | 10.3
| CHD | 54.1 | 39.4 | 6.4
| GIH | 41.6 | 46.5 | 11.9
| LWK | 84.5 | 14.5 | 0.9
| MEX | 37.9 | 44.8 | 17.2
| MKK | 72.9 | 25.8 | 1.3
| TSI | 28.4 | 52.0 | 19.6
| HapMapRevision=28
}}[[rs2305480]] is one of several SNPs from a region on chromosome 17q21 that has been linked to risk for [[asthma]].

A total of 651 French patients with [[asthma]], from among 1,621 subjects in 388 families, were analyzed for SNPs in the (17q21) region. An association was found between this SNP and early-onset [[asthma]] (but not with later onset asthma) which was significant after correction at p < 0.001. Upon further study, this association was seen primarily only in children exposed to tobacco smoke. The odds ratio was 2.77, based on the most likely assumption that this risk is associated only with the recessive homozygous state (and not the heterozygous state, which is still possible). {{PMID|18923164}}

{{PharmGKB
|RSID=rs2305480
|Name_s=
|Gene_s=GSDMB
|Feature=
|Evidence=PubMed ID:18923164
|Annotation=This variant in the 17q21 region was strongly associated (P<0.001) with early-onset asthma. The study shows that the risk increases further by early-life exposure to environmental tobacco smoke.
|Drugs=
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA162356827
}}

{{PMID Auto GWAS
|PMID=20228799
|Trait=Ulcerative colitis
|Title=Genome-wide association identifies multiple ulcerative colitis susceptibility loci
|RiskAllele=A
|Pval=3E-8
|OR=1.15
|ORtxt=[NR]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20860503
|Trait=None
|Title=A large-scale, consortium-based genomewide association study of asthma
|RiskAllele=G
|Pval=1E-7
|OR=1.18
|ORtxt=[1.11-1.23]
}}

{{omim
|id=611403
|rsnum=2305480
}}

{{omim
|id=612380
|rsnum=2305480
}}

{{PMID Auto
|PMID=22469062
|Title=Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms: Epidemiology and Genetics
}}

{{PMID Auto
|PMID=22370936
|Title=Genetic variants on 17q21 are associated with asthma  in a Han Chinese population
}}

{{PMID Auto
|PMID=19458352
|Title=Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=21506939
|Title=Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort.
}}

{{GET Evidence
|gene=GSDMB
|aa_change=Pro311Ser
|aa_change_short=P311S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2305480
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23154084
|Title=Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes
}}

{{PMID Auto
|PMID=23028483
|Title=Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=24241537
  |Trait=Asthma (childhood, severe)
  |Title=A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
  |RiskAllele=G
  |Pval=6E-23
  |OR=1.32
  |ORtxt=[1.23-1.39]
  }}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}