{{Rsnum
|rsid=2306180
|Gene=GYS2
|Chromosome=12
|position=21560468
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.2479
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GYS2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 68.1 | 29.2 | 2.7
| HCB | 53.3 | 37.2 | 9.5
| JPT | 71.7 | 23.9 | 4.4
| YRI | 49.7 | 41.5 | 8.8
| ASW | 41.1 | 50.0 | 8.9
| CHB | 53.3 | 37.2 | 9.5
| CHD | 48.6 | 39.4 | 11.9
| GIH | 68.3 | 25.7 | 5.9
| LWK | 41.8 | 47.3 | 10.9
| MEX | 65.5 | 32.8 | 1.7
| MKK | 45.5 | 39.7 | 14.7
| TSI | 51.0 | 42.2 | 6.9
| HapMapRevision=28
}}

{{Venter SNP
|rsid=2306180
|allele=C
|frequency=0.183
|uid=1103649388724
|type=heterozygous_SNP
|hugo=GYS2
|ensembl gene=ENSG00000111713
|ensembl transcript=ENST00000261195
|sift=AFFECT FUNCTION
|disease=Defects in GYS2 are the cause of glycogen storage disease type 0 (GSD-0) (MIM:240600); also known as liver glycogen synthase deficiency. It is a rare form of fasting hypoglycemia presenting in infancy or early childhood and accompanied by high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia.
}}

{{GET Evidence
|gene=GYS2
|aa_change=Met363Val
|aa_change_short=M363V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2306180
|overall_frequency_n=7949
|overall_frequency_d=10758
|overall_frequency=0.738892
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=82
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=0
|autoscore=2
|n_web_uneval=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}