{{Rsnum
|rsid=2306536
|Gene=CHFR
|Chromosome=12
|position=132847076
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1662
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CHFR
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 68.8 | 28.6 | 2.7
| HCB | 86.9 | 12.4 | 0.7
| JPT | 93.8 | 6.2 | 0.0
| YRI | 46.9 | 43.5 | 9.5
| ASW | 56.1 | 40.4 | 3.5
| CHB | 86.9 | 12.4 | 0.7
| CHD | 87.0 | 12.0 | 0.9
| GIH | 48.5 | 42.4 | 9.1
| LWK | 60.2 | 37.0 | 2.8
| MEX | 77.6 | 19.0 | 3.4
| MKK | 58.3 | 36.5 | 5.1
| TSI | 51.0 | 45.1 | 3.9
| HapMapRevision=28
}}[[rs2306536]], a SNP in the [[CHFR]] gene, was found to be significantly associated with a lower risk of [[colorectal cancer]] (odd ratio 0.53, CI: 0.30-0.94), and to be significantly correlated with the absence of distant metastases, in a case/control study of ~500 Korean patients. {{PMID|18079053}}

{{GET Evidence
|gene=CHFR
|aa_change=Val539Met
|aa_change_short=V539M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2306536
|overall_frequency_n=23
|overall_frequency_d=126
|overall_frequency=0.18254
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}