{{Rsnum
|rsid=2308321
|Gene=MGMT
|Chromosome=10
|position=131565064
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.06474
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 69.0 | 30.1 | 0.9
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 94.7 | 5.3 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 90.1 | 8.9 | 1.0
| LWK | 99.1 | 0.9 | 0.0
| MEX | 94.8 | 5.2 | 0.0
| MKK | 99.4 | 0.6 | 0.0
| TSI | 78.4 | 21.6 | 0.0
| HapMapRevision=28
}}[[rs2308321]], also known as Ile143Val or I143V, is a SNP in the [[MGMT]] gene. The more common (A) allele encodes the Ile, while the (G) allele encodes the Val. This change at codon 143 is often reported to be linked to a change at codon 178, [[rs2308327]].

{{ neighbor
| rsid = 2308327
| distance = 106
}}

{{PMID Auto
|PMID=21075068
|Title=SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study
}}

{{PMID Auto
|PMID=20938339
|Title=Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients
}}

{{PMID Auto
|PMID=16857995
|Title=Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.
|OA=1
}}

{{PMID Auto
|PMID=17119116
|Title=Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.
|OA=1
}}

{{PMID Auto
|PMID=17482892
|Title=Human variants of O6-alkylguanine-DNA alkyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18796628
|Title=Etiologic heterogeneity among non-Hodgkin lymphoma subtypes.
|OA=1
}}

{{PMID Auto
|PMID=18990748
|Title=International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
|OA=1
}}

{{PMID Auto
|PMID=19124499
|Title=Association and interactions between DNA repair gene polymorphisms and adult glioma.
|OA=1
}}

{{PMID Auto
|PMID=19181721
|Title=Next generation tools for the annotation of human SNPs.
|OA=1
}}

{{PMID Auto
|PMID=19438866
|Title=Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.
|OA=1
}}

{{GET Evidence
|gene=MGMT
|aa_change=Ile143Val
|aa_change_short=I143V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2308321
|overall_frequency_n=8
|overall_frequency_d=128
|overall_frequency=0.0625
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.007
|nblosum100=-4
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24238921
|Title=Identification of methylguanine methyltransferase polymorphisms as genetic markers of individual susceptibility to therapy-related myeloid neoplasms
}}

{{PMID Auto
|PMID=24552298
|Title=Association Between Six Genetic Polymorphisms and Colorectal Cancer: A Meta-Analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}