{{Rsnum
|rsid=2308327
|Gene=MGMT
|Chromosome=10
|position=131565170
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.06474
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 70.3 | 28.8 | 0.9
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 94.7 | 5.3 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 90.1 | 8.9 | 1.0
| LWK | 99.1 | 0.9 | 0.0
| MEX | 94.8 | 5.2 | 0.0
| MKK | 99.4 | 0.6 | 0.0
| TSI | 78.4 | 21.6 | 0.0
| HapMapRevision=28
}}
[[rs2308327]], also known as K178R, is a SNP in the [[MGMT]] gene. The more common allele, [[rs2308327]](A), encodes a lysine (K) at codon 178, while the (G) allele encodes an arginine (R).

In a pooled analysis of 200+ lung cancer patients, the [[rs2308327]](G) allele was reported to provide a protective effect against [[lung cancer]], and furthermore, more (G) alleles meant more protection, particularly for smokers. The odds ratios reported (p=0.003) were 0.67 (CI: 0.45-1.01) for heterozygotes, and 0.10 (CI: 0.01-0.94) for [[rs2308327]](G;G) homozygotes.{{PMID|17957803}}

In a study of 300+ [[colon cancer]] cases, [[rs2308327]](G), in linkage disequilibrium with the previously reported MGMT Ile(143)Val [[rs2308321]] SNP, had an inverse association with [[colorectal cancer]] risk (odds ratio 0.52, CI: 0.35-0.78, unadjusted p(trend) = 0.0003 for the additive model).{{PMID|18268114}} 

{{ neighbor
| rsid = 2308321
| distance = 106
}}

{{PMID Auto
|PMID=20938339
|Title=Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients
}}

{{PMID Auto
|PMID=16385451
|Title=A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
|OA=1
}}

{{PMID Auto
|PMID=16857995
|Title=Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.
|OA=1
}}

{{PMID Auto
|PMID=17119116
|Title=Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.
|OA=1
}}

{{PMID Auto
|PMID=17482892
|Title=Human variants of O6-alkylguanine-DNA alkyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18990748
|Title=International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
|OA=1
}}

{{PMID Auto
|PMID=19124499
|Title=Association and interactions between DNA repair gene polymorphisms and adult glioma.
|OA=1
}}

{{GET Evidence
|gene=MGMT
|aa_change=Lys178Arg
|aa_change_short=K178R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2308327
|overall_frequency_n=8
|overall_frequency_d=128
|overall_frequency=0.0625
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=0
|n_articles_annotated=0
|nblosum100=-3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24238921
|Title=Identification of methylguanine methyltransferase polymorphisms as genetic markers of individual susceptibility to therapy-related myeloid neoplasms
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}