{{Rsnum
|rsid=2319398
|Gene=GSK3B
|Chromosome=3
|position=119894095
|Orientation=minus
|GMAF=0.4518
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=GSK3B
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 43.4 | 47.8 | 8.8
| HCB | 21.9 | 54.7 | 23.4
| JPT | 22.1 | 46.0 | 31.9
| YRI | 0.0 | 3.4 | 96.6
| ASW | 1.8 | 29.8 | 68.4
| CHB | 21.9 | 54.7 | 23.4
| CHD | 17.4 | 51.4 | 31.2
| GIH | 24.8 | 47.5 | 27.7
| LWK | 0.0 | 12.7 | 87.3
| MEX | 39.7 | 51.7 | 8.6
| MKK | 5.1 | 37.2 | 57.7
| TSI | 29.4 | 56.9 | 13.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2319398
|Name_s=GSK3B: IVS7+9227 A>G
|Gene_s=GSK3B
|Feature=
|Evidence=PubMed ID:18195730
|Annotation=This variant is associated with antidepressant treatment response in Chinese major depressive disorder. In a four-locus haplotype analysis (rs334558; rs13321783; rs2319398; rs6808874), the GSK3B TAGT carriers showed a poorer response to antidepressants than carriers with other haplotype groups.
|Drugs=citalopram; fluoxetine
|Drug Classes=
|Diseases=Depression; Depressive Disorder, Major
|Curation Level=Curated
|PharmGKB Accession ID=PA162369930
}}

{{PMID Auto
|PMID=17270183
|Title=Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome.
|OA=1
}}

{{PMID Auto
|PMID=18195729
|Title=Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder.
}}

{{PMID Auto
|PMID=18676680
|Title=Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2319398
|overall_frequency_n=72
|overall_frequency_d=128
|overall_frequency=0.5625
|n_genomes=43
|n_genomes_annotated=0
|n_haplomes=69
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}