{{Rsnum
|rsid=2322659
|Gene=LCT
|Chromosome=2
|position=135798089
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.4885
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=LCT
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 68.1 | 25.7 | 6.2
| HCB | 19.0 | 48.9 | 32.1
| JPT | 24.8 | 53.1 | 22.1
| YRI | 6.8 | 33.3 | 59.9
| ASW | 14.0 | 43.9 | 42.1
| CHB | 19.0 | 48.9 | 32.1
| CHD | 17.4 | 62.4 | 20.2
| GIH | 13.9 | 51.5 | 34.7
| LWK | 5.5 | 37.3 | 57.3
| MEX | 32.8 | 39.7 | 27.6
| MKK | 0.0 | 14.1 | 85.9
| TSI | 14.7 | 47.1 | 38.2
| HapMapRevision=28
}}{{Venter SNP
|rsid=2322659
|allele=C
|frequency=0.833
|uid=1103658227778
|type=homozygous_SNP
|hugo=LCT
|ensembl gene=ENSG00000115850
|ensembl transcript=ENST00000264162
|sift=AFFECT FUNCTION
|disease=Defects in the upstream vicinity of LCT are the cause of disaccharide intolerance III (MIM:223100); also known as adult lactase deficiency or adult-type hypolactasia. In many human populations the activity of LCT declines in adults, leading to adult-type hypolactasia, whereas in other populations the high activity persists.
}}

{{PMID Auto
|PMID=15114531
|Title=Genetic signatures of strong recent positive selection at the lactase gene.
|OA=1
}}

{{PMID Auto
|PMID=19326473
|Title=Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
|OA=1
}}

{{PMID Auto
|PMID=20017971
|Title=Assessing the impact of global versus local ancestry in association studies.
|OA=1
}}

{{PMID Auto
|PMID=20031626
|Title=Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.
|OA=1
}}

{{GET Evidence
|gene=LCT
|aa_change=Asn1639Ser
|aa_change_short=N1639S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2322659
|overall_frequency_n=6588
|overall_frequency_d=10758
|overall_frequency=0.612381
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=55
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=0
|autoscore=2
|n_web_uneval=1
}}

{{PMID Auto
|PMID=23420841
|Title=Genetic dissection of the preeclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}