{{Rsnum
|rsid=2333227
|Gene=MPO
|Chromosome=17
|position=58281401
|Orientation=plus
|GMAF=0.2273
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MPO
}}[[rs2333227]] is a SNP in the promoter region of the myeloperoxidase [[MPO]] gene; it is also known as the -463 variant. It has been implicated in [[Alzheimer's disease]], [[lung cancer]], [[gastric cancer]], and [[lupus]] nephritis in SLE patients.

In connection with [[Alzheimer's disease]] (AD):

* A study of 127 Finnish patients concluded that the [[rs2333227]](T) allele increased the risk of [[Alzheimer's disease]] by 3.8 fold. This was derived by noting that a man with an [[ApoE]] allele has an AD odds ratio of 3.0 if they don't also have an [[rs2333227]](T) allele, and an odds ratio of 11.4 if they do.{{PMID|11087769}}

* A study of 148 Italian sporadic AD patients yielded an odds ratio for the [[rs2333227]](C;C) genotype (as oriented in dbSNP orientation) of 1.78 (CI: 1.13-2.80). The presence of [[rs669]](G;G), in addition to [[rs2333227]](C;C), appears to  synergistically increase the risk of AD to an odds ratio of 25.5 (CI: 4.65-139.75), regardless of [[ApoE]] status.{{PMID|15023809}}

In connection with [[lung cancer]]:

* A pooled analysis of data from 10 studies (3688 cases) found an odds ratio for [[lung cancer]] of 0.88 (CI: 0.80-0.97) for [[rs2333227]](C;T) heterozygotes, and 0.71 (CI: 0.57-0.88) for (T;T) homozygotes. This protective effect applied to both men and women, and appeared to apply to "ever" smokers but not "never" smokers.{{PMID|17304047}}

In connection with [[lupus]] nephritis:

* While there was no association with [[lupus]] (SLE) per se in this study of 200+ African-American patients, the risk of developing lupus nephritis among SLE patients was significantly higher among [[rs2333227]](C;T) heterozygotes compared with (C;C) homozygotes (odds ratio 2.11, CI: 1.12-3.97), and it was even higher for (T;T) homozygotes versus (C;C) (odds ratio 3.52, CI: 1.41-8.77).{{PMID|17896805|OA=1
}}

In connection with [[gastric cancer]]:

* [[rs2333227]](T) carriers are at increased risk for gastric cancer, based on a study of 157 Taiwanese patients. If they are also H. pylori-infected, they have a 7.9x increased risk of [[gastric cancer]], either intestinal or diffuse types.{{PMID|18505072}}

{{PMID Auto
|PMID=20663217
|Title=Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China
|OA=1
}}

{{PMID Auto
|PMID=21795425
|Title=Genetic Variation in Myeloperoxidase Modifies the Association of Serum {alpha}-Tocopherol with Aggressive Prostate Cancer among Current Smokers
|OA=1
}}

{{PMID Auto
|PMID=22427832
|Title=Menopausal Status Modifies Breast Cancer Risk Associated with the Myeloperoxidase (MPO) G463A Polymorphism in Caucasian Women: A Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=15576619
|Title=Hematotoxicity in workers exposed to low levels of benzene.
|OA=1
}}

{{PMID Auto
|PMID=16385446
|Title=A testing framework for identifying susceptibility genes in the presence of epistasis.
|OA=1
}}

{{PMID Auto
|PMID=17885617
|Title=Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.
}}

{{PMID Auto
|PMID=18214807
|Title=Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery.
}}

{{PMID Auto
|PMID=18296681
|Title=Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort.
|OA=1
}}

{{PMID Auto
|PMID=18340529
|Title=A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18632753
|Title=Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=19438866
|Title=Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.
|OA=1
}}

{{PMID Auto
|PMID=19479063
|Title=Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
|OA=1
}}

{{PMID Auto
|PMID=20445800
|Title=Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy.
|OA=1
}}

{{PMID Auto
|PMID=21950958
|Title=Plasma myeloperoxidase level and peripheral arterial disease.
}}

{{PMID Auto
|PMID=23167629
|Title=Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review
}}

{{PMID Auto
|PMID=24567965
|Title=Haptoglobin and myeloperoxidase (- G463A) gene polymorphisms in Brazilian sickle cell patients with and without secondary iron overload
}}

{{PMID Auto
|PMID=23175176
|Title=Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.
}}

{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}