{{Rsnum
|rsid=2338104
|Gene=KCTD10
|Chromosome=12
|position=109457363
|Orientation=plus
|GMAF=0.4674
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=KCTD10
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 23.9 | 48.7 | 27.4
| HCB | 42.3 | 47.4 | 10.2
| JPT | 52.2 | 42.5 | 5.3
| YRI | 1.4 | 40.4 | 58.2
| ASW | 3.5 | 54.4 | 42.1
| CHB | 42.3 | 47.4 | 10.2
| CHD | 38.5 | 45.9 | 15.6
| GIH | 50.5 | 38.6 | 10.9
| LWK | 7.3 | 38.2 | 54.5
| MEX | 22.4 | 55.2 | 22.4
| MKK | 27.6 | 48.7 | 23.7
| TSI | 15.8 | 42.6 | 41.6
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs2338104
|PubMedID=18193043
|Condition=HDL cholesterol
|Gene=MVK,MMAB
|Risk Allele=G
|pValue=3.00E-008
|OR=0.48
|95CI=NR) mg/dl highe
}}

{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=C
|Pval=1E-10
|OR=0.07
|ORtxt=[0.03-0.11] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs2338104
|Name_s=
|Gene_s=KCTD10
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 12q24.11; Reported Gene(s): MMAB,MVK; Risk Allele: rs2338104-C); (p-value= 0.0000000001).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740240
}}

{{PharmGKB
|RSID=rs2338104
|Name_s=
|Gene_s=KCTD10
|Feature=
|Evidence=PubMed ID:18193043; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Initial Sample Size: 8,656 individuals; Replication Sample Size: 11,399 individuals; Risk Allele: rs2338104-G). This variant is associated with HDL cholesterol levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356712
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19060911
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20160193
|Title=Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
|OA=1
}}

{{PMID Auto
|PMID=20385826
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2338104
|overall_frequency_n=61
|overall_frequency_d=128
|overall_frequency=0.476562
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=56
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}