{{Rsnum
|rsid=2352028
|Gene=GPC5
|Chromosome=13
|position=91792975
|Orientation=plus
|GMAF=0.3636
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GPC5
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 58.4 | 35.4 | 6.2
| HCB | 49.6 | 43.1 | 7.3
| JPT | 38.1 | 53.1 | 8.8
| YRI | 15.6 | 44.9 | 39.5
| ASW | 17.5 | 54.4 | 28.1
| CHB | 49.6 | 43.1 | 7.3
| CHD | 63.3 | 33.0 | 3.7
| GIH | 75.2 | 20.8 | 4.0
| LWK | 17.3 | 50.9 | 31.8
| MEX | 39.7 | 44.8 | 15.5
| MKK | 12.8 | 43.6 | 43.6
| TSI | 55.9 | 33.3 | 10.8
| HapMapRevision=28
}}[http://www.nhs.uk/news/2010/03March/Pages/Lung-cancer-gene-in-non-smokers.aspx news] increased risk of [[lung cancer]] in non smokers. Analysis showed that the presence of this variant significantly increased the risk of a never smoker having lung cancer by 1.46 times (odds ratio 1.46, 95% confidence interval 1.26 to 1.70).

{{PMID Auto
|PMID=20304703
|Title=Genetic variants and risk of lung cancer in never smokers: a genome-wide association study
|OA=1
}}

{{PharmGKB
|RSID=rs2352028
|Name_s=variant at 13q31.3 that effects GPC5
|Gene_s=GPC5
|Feature=
|Evidence=PubMed ID:20304703
|Annotation=Risk or phenotype-associated allele: Not specified. Phenotype: This variant was asssociated with risk for lung cancer in never smokers in a GWAS and validated and replicated in two further cohorts. Study size: 754 (GWAS); 988 (validation); 530 (replication). Study population/ethnicity: Never smokers; USA. Significance metric(s): OR = 1.46 (95% CI 1.26-1.70; p = 5.94x10(-6). Type of association: CO.
|Drugs=
|Drug Classes=
|Diseases=Lung Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA165291927
}}

{{PMID Auto
|PMID=22236185
|Title=GPC5 rs2352028 Polymorphism and Risk of Lung Cancer in Han Chinese
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2352028
|overall_frequency_n=52
|overall_frequency_d=128
|overall_frequency=0.40625
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24456789
|Title=Variants in the 5'-upstream region of GPC5 confer risk of lung cancer in never smokers
}}

{{PMID Auto
|PMID=23297363
|Title=Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}