{{Rsnum
|rsid=2363956
|Gene=ANKLE1
|Chromosome=19
|position=17283315
|Orientation=plus
|GMAF=0.4504
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ANKLE1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 31.9 | 46.0 | 22.1
| HCB | 15.6 | 37.8 | 46.7
| JPT | 12.4 | 35.4 | 52.2
| YRI | 29.9 | 52.4 | 17.7
| ASW | 26.3 | 49.1 | 24.6
| CHB | 15.6 | 37.8 | 46.7
| CHD | 8.3 | 45.4 | 46.3
| GIH | 16.8 | 54.5 | 28.7
| LWK | 19.1 | 55.5 | 25.5
| MEX | 17.2 | 43.1 | 39.7
| MKK | 27.6 | 50.0 | 22.4
| TSI | 33.3 | 45.1 | 21.6
| HapMapRevision=28
}}[[breast cancer]] http://www.nature.com/ng/journal/v42/n10/full/ng.669.html

This SNP is associated with risk of [[breast cancer]]. {{PMID|20852631|OA=1
}}

{{PMID Auto GWAS
|PMID=20852633
|Trait=None
|Title=Common variants at 19p13 are associated with susceptibility to ovarian cancer
|RiskAllele=T
|Pval=1E-7
|OR=1.10
|ORtxt=[1.06-1.15]
|OA=1
}}

{{PMID Auto
|PMID=22235027
|Title=Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer.
|OA=1
}}

{{GET Evidence
|gene=ANKLE1
|aa_change=Leu184Trp
|aa_change_short=L184W
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2363956
|overall_frequency_n=5523
|overall_frequency_d=10756
|overall_frequency=0.513481
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=0
|n_articles_annotated=0
|nblosum100=5
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23133607
|Title=Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=24325915
  |Trait=Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)
  |Title=Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.
  |RiskAllele=C
  |Pval=2E-8
  |OR=1.22
  |ORtxt=[1.14-1.3]
  }}

{{PMID Auto
|PMID=25173882
|Title=Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}