{{Rsnum
|rsid=237025
|Gene=SUMO4
|Chromosome=6
|position=149400554
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3714
|Gene_s=SUMO4,TAB2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 27.4 | 45.1 | 27.4
| HCB | 7.3 | 40.9 | 51.8
| JPT | 8.0 | 42.5 | 49.6
| YRI | 9.6 | 34.2 | 56.2
| ASW | 7.0 | 22.8 | 70.2
| CHB | 7.3 | 40.9 | 51.8
| CHD | 6.4 | 40.4 | 53.2
| GIH | 13.9 | 59.4 | 26.7
| LWK | 2.7 | 22.7 | 74.5
| MEX | 13.8 | 56.9 | 29.3
| MKK | 7.1 | 31.0 | 61.9
| TSI | 33.3 | 42.2 | 24.5
| HapMapRevision=28
}}{{PMID|17374705}} suggested the contribution of [[rs237025]] to type-1 diabetes, however in {{PMID|19956095|OA=1
}} this failed to replicate.

This SNP is also known as Met55Val, M55V, or A163G.

This was the first [[SNP]] in [[SNPedia]].

{{omim
|id=608829
|rsnum=237025
|variant=0001
}}

{{ClinVar
|rsid=237025
|Reversed=1
|FwdREF=C
|FwdALT=T
|REF=G
|ALT=A
|RSPOS=149721690
|CHROM=6
|GMAF=0.3713
|dbSNPBuildID=79
|SSR=0
|SAO=1
|VP=0x05036800000017051f110100
|GENEINFO=TAB2:23118; SUMO4:387082
|GENE_NAME=TAB2; SUMO4
|GENE_ID=23118; 387082
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000006.11:g.149721690G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=608829.0001
|CLNSIG=255
|CLNCUI=C1838260
|CLNDBN=Diabetes mellitus, insulin-dependent, 5
|Disease=Diabetes mellitus
|CLNACC=RCV000002143.1
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.3714; 0.6286
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1838260:600320
|COMMON=1
}}

{{PMID|16159953}} The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis.

{{PMID|16380915|OA=1
}} Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

{{PMID|16735488}} Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.

{{PMID|17229939}} SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes.

{{PMID|18330586}} Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris.

{{PMID|18466472|OA=1
}} Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.

{{PMID|18466513|OA=1
}} Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.

{{PMID|18466531|OA=1
}} Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.

{{PMID|18466554|OA=1
}} Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests.

{{PMID|18466563|OA=1
}} Classification of rheumatoid arthritis status with candidate gene and genome-wide single-nucleotide polymorphisms using random forests.

{{PMID|18560894|OA=1
}} Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population.

{{PMID|19122825|OA=1
}} Small ubiquitin-like modifier 4 (SUMO4) polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population.

{{PMID|19956101|OA=1
}} Overview of the Rapid Response data.

{{PMID|19956109|OA=1
}} The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

{{GET Evidence
|gene=SUMO4
|aa_change=Val55Met
|aa_change_short=V55M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs237025
|overall_frequency_n=6047
|overall_frequency_d=10758
|overall_frequency=0.562093
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=79
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23042402
|Title=[Association between SUMO4 polymorphisms and coronary artery disease with and without type 2 diabetes mellitus]
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}