{{Rsnum
|rsid=2373115
|Gene=GAB2
|Chromosome=11
|position=78380104
|Orientation=minus
|GMAF=0.292
|Gene_s=GAB2,PPIAP5
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 77.0 | 20.4 | 2.7
| HCB | 40.9 | 43.1 | 16.1
| JPT | 26.5 | 50.4 | 23.0
| YRI | 42.9 | 46.9 | 10.2
| ASW | 33.3 | 52.6 | 14.0
| CHB | 40.9 | 43.1 | 16.1
| CHD | 34.9 | 54.1 | 11.0
| GIH | 43.6 | 48.5 | 7.9
| LWK | 41.7 | 52.8 | 5.6
| MEX | 46.6 | 43.1 | 10.3
| MKK | 32.1 | 51.9 | 16.0
| TSI | 57.4 | 38.6 | 4.0
| HapMapRevision=28
}}Conflicting reports of possible small increase in Alzheimer's risk. Currently dubious at best.

[[rs2373115]] is one of several SNPs in the [[GAB2]] gene indicating an increased risk (OR 4.1) of late-onset [[Alzheimer's disease]], but apparently only in individuals also carrying [[ApoE4]] alleles, i.e. [[rs429358]](C) alleles {{PMID|17553421|OA=1
}}

{{PMID|19262956}} rs2373115 marker does not modify the risk of Alzheimer's disease in Spanish APOE e4 carriers.

[[rs2373115]](G) is the risk allele.

{{PMID|17553421|OA=1
}} (p = 9 x 10(-11)) was associated with an odds ratio of 4.06 (confidence interval 2.81-14.69)

However, a separate study of 1,749 Alzheimer patients concluded that this [[GAB2]] SNP is "at best a minor genetic determinant" since the authors of this study observed only a slight tendency for an increase of the (G;G) genotype (odds ratio of 1.3 vs (G;T) and (T;T), CI:1.0-1.6, p=0.09) and for an increase in the G allele frequency (odds ratio 1.3, CI:1.0-1.6, p=0.05) in [[ApoE4]]-carriers.{{PMID|18272374}}  

{{PMID|19118819}} A new (Dec 2008) meta-analysis concludes that, yes, indeed, [[rs2373115]] is associated with increased risk for [[Alzheimer's disease]] among [[ApoE4]] carriers, with an odds ratio of 1.58 (CI: 1.17 - 2.14, p = 3 x 10e-3), but only among carriers. This meta-analysis pooled published studies with a new study of 443 AD cases.

{{PMID|19276544}} A study of 579 Italian Alzheimer's patients saw this association, but only in ApoE4 non-carriers, suggesting it might be an independent risk factor for the disease.

{{GWAS Summary
|SNP=rs2373115
|PubMedID=17553421
|Condition=APOE*e4 carriers with late onset Alzheimer's disease
|Gene=GAB2
|Risk Allele=G
|pValue=1.00E-010
|OR=4.06
|95CI=2.81-14.69
|OA=1
}}

{{omim
|desc=ALZHEIMER DISEASE; AD
|id=104300
|rsnum=2373115
}}

{{omim
|desc=GRB2-ASSOCIATED BINDING PROTEIN 2; GAB2
|id=606203
|rsnum=2373115
}}

{{PharmGKB
|RSID=rs2373115
|Name_s=
|Gene_s=GAB2
|Feature=
|Evidence=PubMed ID:17553421; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers (Initial Sample Size: 446 cases, 290 controls; Replication Sample Size: 415 cases, 260 controls; Risk Allele: rs2373115-G).
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356629
}}

{{PMID Auto
|PMID=21285854
|Title=Association Study of the GAB2 Gene With the Risk of Alzheimer Disease in the Chinese Population
}}

{{PMID Auto
|PMID=19204163
|Title=GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results.
|OA=1
}}

{{PMID Auto
|PMID=19924507
|Title=GAB2 is not associated with late-onset Alzheimer's disease in Chinese Han.
}}

{{PMID Auto
|PMID=20061627
|Title=Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=20188796
|Title=Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients.
}}

{{PMID Auto
|PMID=20574532
|Title=Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2373115
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24161894
|Title=GAB2 polymorphism rs2373115 confers susceptibility to sporadic Alzheimer's disease
}}

{{PMID Auto
|PMID=23525328
|Title=Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}