{{Rsnum
|rsid=2383206
|Gene=CDKN2BAS
|Chromosome=9
|position=22115027
|Orientation=plus
|GMAF=0.4917
|Gene_s=CDKN2B-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 18.5 | 56.9 | 24.6
| HCB | 28.9 | 51.1 | 20.0
| JPT | 25.0 | 50.0 | 25.0
| YRI | 33.3 | 47.6 | 19.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 28.9 | 51.1 | 20.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs10757274]] and [[rs2383206]] can significantly increase the risk of [[heart disease]][http://www.sciencemag.org/cgi/content/short/316/5830/1488]. About one in every four Caucasians are thought to carry the variants, and their risk of coronary heart disease is increased by 30 to 40%. [[rs10757278]] in the same region has been linked to [[diabetes]] [http://www.forbes.com/forbeslife/health/feeds/hscout/2007/05/03/hscout604291.html]. The chromosomal region where these SNPs are located is 9p21, and has no known genes.

a [http://suicyte.wordpress.com/2007/05/26/soul-searching-i/ blog post]  about investigating [[rs10757274]] and [[rs2383206]]
{{ neighbor
| rsid = 2383207
| distance = 933
}}

{{PMID|18048766}} This SNP was also associated with increased risk for [[coronary artery disease]] in a Korean population.

{{PMID|18066490}} Also found to be significant in a study of 416 Italian myocardial infarction patients.

A study of 1,000+ patients with early-onset angiographic [[coronary artery disease]] (CAD) concluded that [[rs2383206]](G) was associated with an adjusted odds ratio of 1.39 (CI: 1.05-1.85) for (A;G) heterozygotes and 1.73 (CI: 1.26-2.37) for (G;G) homozygotes. This SNP alone accounted for 21% of the [http://www.snpedia.com/index.php/Glossary#population population attributable fraction] and was independent of traditional risk factors, myocardial infarction risk, and the extent of disease.{{PMID| 19033013}}

{{omim
|desc=CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 8; CHDS8
|id=611139
|rsnum=2383206
}}
{{PMID Auto
|PMID=19559344
|Title=Genetic variants on chromosome 9p21 and ischemic stroke in Chinese
}}

{{PMID Auto
|PMID=20031605
|Title=9p21 is a Shared Susceptibility Locus Strongly for Coronary Artery Disease and Weakly for Ischemic Stroke in Chinese Han Population
}}

{{PMID Auto
|PMID=21375403
|Title=The Relationship Between Polymorphisms on Chromosome 9p21 and Age of Onset of Coronary Heart Disease in Black and White Women
|OA=1
}}

{{PMID Auto
|PMID=20718794
|Title=Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS
}}

{{PMID Auto
|PMID=21385355
|Title=Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry
|OA=1
}}

{{PMID Auto
|PMID=22622453
|Title=The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus
}}

{{PMID Auto
|PMID=18362232
|Title=Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=18443000
|Title=Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study.
|OA=1
}}

{{PMID Auto
|PMID=18505420
|Title=Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).
|OA=1
}}

{{PMID Auto
|PMID=18620593
|Title=Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome.
|OA=1
}}

{{PMID Auto
|PMID=18704761
|Title=Molecular genetics of myocardial infarction.
|OA=1
}}

{{PMID Auto
|PMID=18757290
|Title=Associations between single nucleotide polymorphisms on chromosome 9p21 and risk of coronary heart disease in Chinese Han population.
}}

{{PMID Auto
|PMID=18957718
|Title=Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population.
|OA=1
}}

{{PMID Auto
|PMID=18987759
|Title=Genetic testing for atherosclerosis risk: inevitability or pipe dream?
|OA=1
}}

{{PMID Auto
|PMID=19033589
|Title=Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19173706
|Title=The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=19329499
|Title=A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study.
|OA=1
}}

{{PMID Auto
|PMID=19379518
|Title=Development of a fingerprinting panel using medically relevant polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19578366
|Title=Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=19888323
|Title=Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants.
|OA=1
}}

{{PMID Auto
|PMID=19956433
|Title=Genetics of coronary artery disease: focus on genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=19956784
|Title=Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20386740
|Title=Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.
|OA=1
}}

{{PMID Auto
|PMID=20565774
|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{PMID Auto
|PMID=23086272
|Title=Association between 9p21.3 genomic markers and coronary artery disease in East Asians: a meta-analysis involving 9,813 cases and 10,710 controls
}}

{{PMID Auto
|PMID=23134948
|Title=Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15)
|OA=1
}}

{{PMID Auto
|PMID=23388737
|Title=Association of Single Nucleotide Polymorphisms on Chromosome 9p21.3 With Cardiovascular Death in Kidney Transplant Recipients
}}

{{PMID Auto
|PMID=22975211
|Title=Meta-analysis of genetic association of chromosome 9p21 with early-onset coronary artery disease.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}