{{Rsnum
|rsid=2383207
|Gene=CDKN2BAS
|Chromosome=9
|position=22115960
|Orientation=plus
|GMAF=0.3324
|Gene_s=CDKN2B-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 25.7 | 52.2 | 22.1
| HCB | 9.5 | 51.1 | 39.4
| JPT | 9.7 | 38.9 | 51.3
| YRI | 0.0 | 3.4 | 96.6
| ASW | 0.0 | 19.3 | 80.7
| CHB | 9.5 | 51.1 | 39.4
| CHD | 12.8 | 42.2 | 45.0
| GIH | 14.9 | 57.4 | 27.7
| LWK | 0.0 | 10.0 | 90.0
| MEX | 15.5 | 53.4 | 31.0
| MKK | 0.6 | 10.3 | 89.1
| TSI | 16.7 | 52.0 | 31.4
| HapMapRevision=28
}}discussed in this [http://suicyte.wordpress.com/2007/05/26/soul-searching-i/ blog post] as possibly playing a role in [[coronary heart disease]]

{{PMID|18048766}} This SNP was also associated with increased risk for [[coronary artery disease]] in a Korean population.

The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54).

{{PMID|18066490}} Also found to be significant in a study of 416 Italian myocardial infarction patients.

{{PMID|18757290}} Found to be associated with [[coronary heart disease]] in a study of 1360 Chinese Han patients, with an odds ratio of 1.52 (CI: 1.13 - 2.04) for [[rs2383207]](G;G) individuals. This risk was magnified in subjects who were males, less than 60 years old, overweight, or smokers.

{{ neighbor
| rsid = 2383206
| distance = 933
}}

{{omim
|desc=CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 8; CHDS8
|id=611139
|rsnum=2383207
}}
{{PMID Auto
|PMID=19293724
|Title=The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension
}}
{{PMID Auto
|PMID=19901189
|Title=A Common Variant at 9p21 Is Associated With Sudden and Arrhythmic Cardiac Death
|OA=1
}}

{{PMID Auto
|PMID=20031580
|Title=Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study
}}

{{PMID Auto GWAS
|PMID=20622881
|Trait=Abdominal aortic aneurysm
|Title=Genome-wide association study identifies a sequence variant with the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
|RiskAllele=G
|Pval=2E-8
|OR=1.27
|ORtxt=[NR]
}}
{{PMID Auto
|PMID=21152093
|Title=Sex Differential Genetic Effect of Chromosome 9p21 on Subclinical Atherosclerosis
|OA=1
}}

{{PMID Auto
|PMID=22122968
|Title=Additive Effect of ANRIL and BRAP Polymorphisms on Ankle-Brachial Index in a Taiwanese Population
}}

{{PMID Auto
|PMID=21385355
|Title=Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry
|OA=1
}}

{{PMID Auto
|PMID=18362232
|Title=Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=18459066
|Title=A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease.
}}

{{PMID Auto
|PMID=18505420
|Title=Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).
|OA=1
}}

{{PMID Auto
|PMID=18620593
|Title=Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome.
|OA=1
}}

{{PMID Auto
|PMID=18704761
|Title=Molecular genetics of myocardial infarction.
|OA=1
}}

{{PMID Auto
|PMID=18987759
|Title=Genetic testing for atherosclerosis risk: inevitability or pipe dream?
|OA=1
}}

{{PMID Auto
|PMID=19173706
|Title=The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=19463184
|Title=Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.
|OA=1
}}

{{PMID Auto
|PMID=19475673
|Title=Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke.
|OA=1
}}

{{PMID Auto
|PMID=19819472
|Title=Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery.
|OA=1
}}

{{PMID Auto
|PMID=19888323
|Title=Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants.
|OA=1
}}

{{PMID Auto
|PMID=19956784
|Title=Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20386740
|Title=Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.
|OA=1
}}

{{PMID Auto
|PMID=20718794
|Title=Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS.
}}

{{PMID Auto
|PMID=20858033
|Title=Haplotypes on 9p21 modify the risk for coronary artery disease among Indians.
}}

{{PMID Auto
|PMID=21415773
|Title=Chromosome 9p21 genetic variants are associated with myocardial infarction but not with ischemic stroke in a Taiwanese population.
}}

{{PMID Auto
|PMID=23343465
|Title=Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=23535969
|Title=Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome
}}

{{PMID Auto
|PMID=22882272
|Title=Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke.
|OA=1
}}

{{PMID Auto
|PMID=22975211
|Title=Meta-analysis of genetic association of chromosome 9p21 with early-onset coronary artery disease.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}