{{Rsnum
|rsid=2395185
|Chromosome=6
|position=32465390
|Orientation=plus
|GMAF=0.292
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 33.9 | 45.5 | 20.5
| HCB | 39.3 | 48.1 | 12.6
| JPT | 35.5 | 51.8 | 12.7
| YRI | 66.0 | 30.5 | 3.5
| ASW | 64.9 | 29.8 | 5.3
| CHB | 39.3 | 48.1 | 12.6
| CHD | 38.0 | 42.6 | 19.4
| GIH | 48.0 | 42.0 | 10.0
| LWK | 76.4 | 20.8 | 2.8
| MEX | 39.3 | 51.8 | 8.9
| MKK | 53.2 | 35.3 | 11.5
| TSI | 56.6 | 38.4 | 5.1
| HapMapRevision=28
}}A genome-wide association study using DNA samples from 1,052 individuals with [[ulcerative colitis]] and preexisting data from 2,571 controls, all of European ancestry, concluded that this SNP and several others were associated with altered risk for the disease.{{PMID|19122664|OA=1
}}

{{PMID Auto
|PMID=19837788
|Title=Capture of [[type 1 diabetes]]-susceptible HLA DR-DQ haplotypes in Japanese subjects using a tag single nucleotide polymorphism
|OA=1
}}

{{PharmGKB
|RSID=rs2395185
|Name_s=
|Gene_s=HLA-DRB9
|Feature=
|Evidence=PubMed ID:19122664; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (Initial Sample Size: 1,022 cases, 2,503 controls; Replication Sample Size: 1,387 cases, 1,115 controls); (Region: 6p21.32; Reported Gene(s): BTNL2, HLA-DRA, HLA-DRB5, HLA-DRB1, HLA-DQA1, HLA-DQB1; Risk Allele: rs2395185-?); (p-value= 0.0000000000000001).This variant is associated with Ulcerative colitis.
|Drugs=
|Drug Classes=
|Diseases=Colitis, Ulcerative
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740081
}}
{{PMID Auto GWAS
|PMID=19915573
|Trait=Ulcerative colitis
|Title=A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population
|RiskAllele=G
|Pval=5E-22
|OR=1.92
|ORtxt=[1.68-2.19]
}}

{{omim
|id=604519
|rsnum=2395185
}}

{{PMID Auto
|PMID=22286212
|Title=Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups
|OA=1
}}

{{PMID Auto
|PMID=19128478
|Title=Complex nature of SNP genotype effects on gene expression in primary human leucocytes.
|OA=1
}}

{{PMID Auto
|PMID=20017995
|Title=A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies.
|OA=1
}}

{{PMID Auto
|PMID=20018015
|Title=Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20018024
|Title=On the association between rheumatoid arthritis and classical HLA class I and class II alleles predicted from single-nucleotide polymorphism data.
|OA=1
}}

{{PMID Auto
|PMID=20018025
|Title=Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium.
|OA=1
}}

{{PMID Auto
|PMID=20018075
|Title=Genome-wide association study of rheumatoid arthritis by a score test based on wavelet transformation.
|OA=1
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=21304891
|Title=A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=22383892
|Title=Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2395185
|overall_frequency_n=31
|overall_frequency_d=112
|overall_frequency=0.276786
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23143601
  |Trait=Lung cancer
  |Title=Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
  |RiskAllele=T
  |Pval=1E-8
  |OR=1.17
  |ORtxt=[1.11-1.23]
  }}

{{PMID Auto
|PMID=22694930
|Title=Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}