{{Rsnum
|rsid=2398162
|Gene=LOC644192
|Chromosome=15
|position=96287321
|Orientation=plus
|GMAF=0.3095
|Gene_s=LOC100506754
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 58.4 | 36.3 | 5.3
| HCB | 15.3 | 43.8 | 40.9
| JPT | 16.8 | 52.2 | 31.0
| YRI | 88.4 | 10.2 | 1.4
| ASW | 77.2 | 22.8 | 0.0
| CHB | 15.3 | 43.8 | 40.9
| CHD | 10.1 | 36.7 | 53.2
| GIH | 47.5 | 41.6 | 10.9
| LWK | 91.8 | 8.2 | 0.0
| MEX | 46.6 | 41.4 | 12.1
| MKK | 87.8 | 11.5 | 0.6
| TSI | 68.6 | 29.4 | 2.0
| HapMapRevision=28
}}
[[rs2398162]] has been reported in a large study to be associated with [[high blood pressure]].

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 0.97 (CI 0.76-1.25), and for homozygotes, 1.31 (CI 1.03-1.67). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs2398162
|PubMedID=17554300
|Condition=Hypertension
|Gene=NR
|Risk Allele=A
|pValue=6.00E-006
|OR=1.31
|95CI=1.03-1.67
|OA=1
}}

{{PharmGKB
|RSID=rs2398162
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,952 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs2398162-A). This variant is associated with hypertension.
|Drugs=
|Drug Classes=
|Diseases=Hypertension
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356647
}}

{{PMID Auto
|PMID=18523456
|Title=Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program.
|OA=1
}}

{{PMID Auto
|PMID=20018036
|Title=Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=21228780
|Title=Novel genetic variations associated with salt sensitivity in the Korean population.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2398162
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=25
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}