{{Rsnum
|rsid=2404646
|Chromosome=4
|position=135165126
|Orientation=plus
|GMAF=0.1492
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 83.0 | 16.1 | 0.9
| HCB | 78.8 | 21.2 | 0.0
| JPT | 72.6 | 27.4 | 0.0
| YRI | 40.8 | 45.6 | 13.6
| ASW | 56.1 | 38.6 | 5.3
| CHB | 78.8 | 21.2 | 0.0
| CHD | 80.6 | 18.5 | 0.9
| GIH | 70.4 | 29.6 | 0.0
| LWK | 36.4 | 49.5 | 14.0
| MEX | 87.7 | 12.3 | 0.0
| MKK | 40.4 | 48.7 | 10.9
| TSI | 80.2 | 19.8 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2404646
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19268276
|Annotation=In a GWAS of 3497 Dutch subjects from the Netherlands Study of Depression and Anxiety or from the Netherlands Twin Registry, this SNP was found to be associated with Current Smoking (p = 0.000006478;OR for minor allele G:0.546).
|Drugs=nicotine
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164924504
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2404646
|overall_frequency_n=22
|overall_frequency_d=128
|overall_frequency=0.171875
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}