{{Rsnum
|rsid=241448
|Gene=TAP2
|Chromosome=6
|position=32828908
|Orientation=minus
|ReferenceAllele=C
|GMAF=0.2934
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TAP2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 7.2 | 36.0 | 56.8
| HCB | 16.3 | 45.2 | 38.5
| JPT | 11.6 | 48.2 | 40.2
| YRI | 6.8 | 33.3 | 59.9
| ASW | 3.5 | 42.1 | 54.4
| CHB | 16.3 | 45.2 | 38.5
| CHD | 15.7 | 36.1 | 48.1
| GIH | 18.8 | 53.5 | 27.7
| LWK | 9.1 | 30.0 | 60.9
| MEX | 8.8 | 40.4 | 50.9
| MKK | 12.3 | 50.6 | 37.0
| TSI | 4.9 | 41.2 | 53.9
| HapMapRevision=28
}}
While the [[ApoE4]] allele ([[rs429358(C)]]) is widely accepted as the predominant genetic risk factor for [[Alzheimer's disease]], there are likely to be numerous other factors, both genetic and environmental, associated to lesser degrees with susceptibility to the disease. Genes influencing the immune system, and in particular susceptibility to viral infections such as [[herpes]], may be among such factors. {{PMID|16406033}}

This SNP, located in the [[TAP2]] gene and thus implicated in the activation of [[HIV]] and [[HSV-1]] viruses, is seen more commonly in ~300 [[Alzheimer]] patients than in the same number of controls. The risk allele is [[rs241448(C)]]. The odds ratio is reported to be 2.14 (CI: 1.02-2.55) for [[rsrs241448(C;C)]] homozygotes, and 1.51 (CI: 0.80-1.93) for [[rsrs241448(C;T)]] heterozygotes, compared with [[rsrs241448(T;T)]] homozygotes. This may be particularly significant for carriers of [[ApoE4]] alleles. {{PMID|17420072}}

{{ neighbor
| rsid = 241447
| distance = 66
}}

{{ClinVar
|rsid=241448
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=32796685
|CHROM=6
|GMAF=0.2944
|dbSNPBuildID=79
|SSR=0
|SAO=1
|VP=0x05016800000017051f130101
|GENEINFO=TAP2:6891
|GENE_NAME=TAP2
|GENE_ID=6891
|WGT=0
|VC=SNV
|CLNALLE=0
|CLNHGVS=NC_000006.11:g.32796685A\x3d
|CLNSIG=2
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.7066; 0.2934
|CLNACC=RCV000014729.1
|CLNDBN=PEPTIDE TRANSPORTER PSF2 POLYMORPHISM
|CLNORIGIN=1
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=170261.0003
|COMMON=1
|Disease=PEPTIDE TRANSPORTER PSF2 POLYMORPHISM
}}

{{PMID Auto
|PMID=16595160
|Title=A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers.
}}

{{PMID Auto
|PMID=19680542
|Title=Tissue effect on genetic control of transcript isoform variation.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}