{{Rsnum
|rsid=2420946
|Gene=FGFR2
|Chromosome=10
|position=123351324
|Orientation=plus
|GMAF=0.4362
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 31.9 | 43.4 | 24.8
| HCB | 36.8 | 44.9 | 18.4
| JPT | 44.2 | 43.4 | 12.4
| YRI | 17.8 | 49.3 | 32.9
| ASW | 22.8 | 57.9 | 19.3
| CHB | 36.8 | 44.9 | 18.4
| CHD | 41.3 | 47.7 | 11.0
| GIH | 32.0 | 52.0 | 16.0
| LWK | 21.3 | 54.6 | 24.1
| MEX | 29.8 | 45.6 | 24.6
| MKK | 17.9 | 48.7 | 33.3
| TSI | 36.0 | 43.0 | 21.0
| HapMapRevision=28
}}
This SNP is basically a proxy for SNP [[rs1219648]], which represents the SNP in the [[FGFR2]] gene with the strongest association with [[breast cancer]]. {{PMID|17529973|OA=1
}}

{{PMID|18845558}} Based on a study of 1,049 Chinese breast cancer patients, carriers of risk alleles at three SNPs ([[rs2981582]], [[rs1219648]] and [[rs2420946]]) were at 1.36x increased risk for [[breast cancer]] (CI: 1.13-1.62, p = 0.001).

{{ neighbor
| rsid = 2981582
| distance = 993
}}

{{PMID Auto
|PMID=21445572
|Title=Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
}}

{{PMID Auto
|PMID=18285324
|Title=Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.
|OA=1
}}

{{PMID Auto
|PMID=18326623
|Title=Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
|OA=1
}}

{{PMID Auto
|PMID=19223389
|Title=FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.
|OA=1
}}

{{PMID Auto
|PMID=19497954
|Title=Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19500394
|Title=Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19582883
|Title=FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan.
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=20300826
|Title=Current evidence on the relationship between three polymorphisms in the FGFR2 gene and breast cancer risk: a meta-analysis.
}}

{{PMID Auto
|PMID=20364400
|Title=Quantitative assessment of the effect of FGFR2 gene polymorphism on the risk of breast cancer.
}}

{{PMID Auto
|PMID=20554749
|Title=FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.
|OA=1
}}

{{PMID Auto
|PMID=23225170
|Title=Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer in a South-American population
}}

{{PMID Auto
|PMID=24454457
|Title=Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in chinese han women
|OA=1
}}

{{PMID Auto
|PMID=23184080
|Title=Assessing interactions between the associations of fibroblast growth factor receptor 2 common genetic variants and hormone receptor status with breast cancer risk.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}