{{Rsnum
|rsid=242557
|Gene=MAPT
|Chromosome=17
|position=45942346
|Orientation=plus
|GMAF=0.4174
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MAPT
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 11.5 | 58.4 | 30.1
| HCB | 39.0 | 44.9 | 16.2
| JPT | 20.9 | 46.4 | 32.7
| YRI | 11.0 | 46.9 | 42.1
| ASW | 7.1 | 48.2 | 44.6
| CHB | 39.0 | 44.9 | 16.2
| CHD | 41.3 | 46.8 | 11.9
| GIH | 17.0 | 46.0 | 37.0
| LWK | 13.6 | 43.6 | 42.7
| MEX | 16.1 | 39.3 | 44.6
| MKK | 7.7 | 44.2 | 48.1
| TSI | 13.9 | 38.6 | 47.5
| HapMapRevision=28
}}An initial case-control study {{PMID|18841019}} of 300 patients with [[Alzheimer's disease]] found that subjects carrying both the [[rs2071746]](T;T) and [[rs242557]](A;A) genotypes had increased risk, however the confidence interval was huge (CI: 1.12-39.29; p = 0.037) and later studies have either failed to replicate the results or shown them to only partially hold in [[APOE4]] carriers.

{{PMID|19308965}} Reports that they found only "nominally significant" association between Alzheimer's and [[rs242557]] in [[ApoE4]] positive individuals.

{{PMID Auto
|PMID=19912324
|Title=Association of the MAPT locus with Parkinson's disease
|OA=1
}}

{{PMID Auto
|PMID=20951764
|Title=High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal ?-amyloid in Parkinson disease
}}

{{omim
|id=157140
|rsnum=242557
}}

{{PMID Auto GWAS
|PMID=21685912
|Trait=None
|Title=Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
|RiskAllele=
|Pval=9E-18
|OR=1.4300
|ORtxt=[1.32-1.54]
|OA=1
}}

{{PMID Auto
|PMID=17179995
|Title=Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease.
}}

{{PMID Auto
|PMID=17192721
|Title=Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts.
}}

{{PMID Auto
|PMID=17266761
|Title=Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=18065436
|Title=The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family.
|OA=1
}}

{{PMID Auto
|PMID=18072964
|Title=No evidence for association between tau gene haplotypic variants and susceptibility to Creutzfeldt-Jakob disease.
|OA=1
}}

{{PMID Auto
|PMID=18541914
|Title=Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition.
|OA=1
}}

{{PMID Auto
|PMID=19063963
|Title=Genetic susceptibility in Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=19558713
|Title=Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=19879020
|Title=Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy.
}}

{{PMID Auto
|PMID=21391235
|Title=Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.
|OA=1
}}

{{PMID Auto
|PMID=22291217
|Title=An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.
|OA=1
}}

{{PMID Auto
|PMID=23116876
|Title=An exploratory study on STX6, MOBP, MAPT, and EIF2AK3 and late-onset Alzheimer's disease.
}}

{{PMID Auto
|PMID=24923570
|Title=Structural study of the microtubule-associated protein tau locus of Alzheimer's disease in Taiwan
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}