{{Rsnum
|rsid=2427837
|Gene=FCER1A
|Chromosome=1
|position=159288755
|Orientation=plus
|GMAF=0.1538
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FCER1A
}}[[rs2427837]] is a SNP in the gene encoding the alpha chain of the high affinity receptor for IgE ([[FCER1A]]) on chromosome 1q23. High levels of serum IgE are associated with allergies, and are mediators of autoimmune diseases.

An examination of over 11,000 Germans led to the conclusion that [[rs2427837]] (and one other FCER1A SNP, the tightly linked [[rs2251746]]) were strongly associated with high levels of serum IgE. The more common (G) allele was associated with higher serum IgE, and the effect appeared to be additive. Therefore, homozygous [[rs2251746]](G;G) individuals may be at higher risk for atopic [[eczema]] and [[asthma]] than carriers of one or two (A) alleles. {{PMID|18846228|OA=1
}}

{{ population diversity
| geno1 = (A;A)
| geno2 = (A;G)
| geno3 = (G;G)
| CEU | 6.8 | 45.8 | 47.5
| CHB | 0.0 | 8.9 | 91.1
| JPT | 0.0 | 11.1 | 88.9
| YRI | 1.7 | 8.3 | 90.0
}}

{{PMID Auto
|PMID=22222815
|Title=Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population
}}

{{PMID Auto
|PMID=24354852
|Title=A role of FCER1A and FCER2 polymorphisms in IgE regulation
}}

{{PMID Auto
|PMID=23725541
|Title=Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}