{{Rsnum
|rsid=2435357
|Gene=RET
|Chromosome=10
|position=43086608
|Orientation=minus
|GMAF=0.2507
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=RET
}}This SNP, located in the first intron of the [[RET]] gene, has been associated with [[Hirschsprung]] disease. The risk allele (in dbSNP orientation) is [[rs2435357]](A), with greater affect in males. {{PMID|15829955}}

{{PMID Auto
|PMID=19196962
|Title=Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.
|OA=1
}}

{{omim
|id=164761
|desc=REARRANGED DURING TRANSFECTION PROTOONCOGENE; RET
|rsnum=2435357
}}

{{omim
|id=164761
|rsnum=2435357
|variant=0050
}}

{{PMID Auto
|PMID=22325379
|Title=Intronic RET gene variants in Down syndrome-associated Hirschsprung disease in an African population
}}

{{PMID Auto
|PMID=22377709
|Title=Association of genetic polymorphisms in the RET-protooncogene and NRG1 with Hirschsprung disease in Thai patients
}}

{{PMID Auto
|PMID=17091122
|Title=Allele dosage-dependent penetrance of RET proto-oncogene in an Israeli-Arab inbred family segregating Hirschsprung disease.
}}

{{PMID Auto
|PMID=18248681
|Title=Prevalence of common disease-associated variants in Asian Indians.
|OA=1
}}

{{PMID Auto
|PMID=19306335
|Title=Interaction between a chromosome 10 RET enhancer and chromosome 21 in the Down syndrome-Hirschsprung disease association.
|OA=1
}}

{{PMID Auto
|PMID=20089534
|Title=Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease.
}}

{{PMID Auto
|PMID=20361209
|Title=Fine mapping of the 9q31 Hirschsprung's disease locus.
|OA=1
}}

{{PMID Auto
|PMID=20532249
|Title=Haplotype analysis reveals a possible founder effect of RET mutation R114H for Hirschsprung's disease in the Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20598273
|Title=Differential contributions of rare and common, coding and noncoding Ret mutations to multifactorial Hirschsprung disease liability.
|OA=1
}}

{{PMID Auto
|PMID=20977903
|Title=Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression.
}}

{{PMID Auto
|PMID=21283760
|Title=Fine mapping of the NRG1 Hirschsprung's disease locus.
|OA=1
}}

{{PMID Auto
|PMID=23088776
|Title=Absence of the RET+3:T allele in the MTC patients
|OA=1
}}

{{PMID Auto
|PMID=24897126
|Title=RET Variants and Haplotype Analysis in a Cohort of Czech Patients with Hirschsprung Disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}