{{Rsnum
|rsid=243865
|Gene=MMP2
|Chromosome=16
|position=55477894
|Orientation=plus
|GMAF=0.1566
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MMP2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 57.5 | 36.3 | 6.2
| HCB | 82.5 | 16.8 | 0.7
| JPT | 88.5 | 10.6 | 0.9
| YRI | 93.9 | 6.1 | 0.0
| ASW | 87.7 | 12.3 | 0.0
| CHB | 82.5 | 16.8 | 0.7
| CHD | 81.7 | 16.5 | 1.8
| GIH | 76.2 | 22.8 | 1.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 62.1 | 36.2 | 1.7
| MKK | 97.4 | 2.6 | 0.0
| TSI | 55.9 | 36.3 | 7.8
| HapMapRevision=28
}}{{PMID Auto
|PMID=19454611
|Title=Matrix metalloproteinase-2 polymorphisms and breast cancer susceptibility
|OA=1
}}

{{PharmGKB
|RSID=rs243865
|Name_s=MMP2:-1306C>T
|Gene_s=MMP2
|Feature=
|Evidence=PubMed ID:17607721
|Annotation=This promoter variant is associated with increased risk for nasopharyngeal carcinoma in chinese population.
|Drugs=
|Drug Classes=
|Diseases=Nasopharyngeal Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA161615706
}}

{{PMID Auto
|PMID=20808730
|Title=Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas
|OA=1
}}
{{PMID Auto
|PMID=21228795
|Title=Impact of LIMK1, MMP2 and TNF-? variations for intracranial aneurysm in Japanese population
}}

{{PMID Auto
|PMID=21612407
|Title=Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2
}}

{{PMID Auto
|PMID=22621753
|Title=Higher risk of matrix metalloproteinase (MMP-2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP-2) genetic variants to gallbladder cancer
}}

{{PMID Auto
|PMID=21307882
|Title=Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients
}}

{{PMID Auto
|PMID=16356191
|Title=Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=17958893
|Title=Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression.
|OA=1
}}

{{PMID Auto
|PMID=18205826
|Title=The MMP2 rs243865-T allele is not a major genetic factor for rheumatoid arthritis in the French Caucasian population.
}}

{{PMID Auto
|PMID=18784838
|Title=Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.
|OA=1
}}

{{PMID Auto
|PMID=18787887
|Title=Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.
|OA=1
}}

{{PMID Auto
|PMID=18802702
|Title=Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms).
}}

{{PMID Auto
|PMID=19379518
|Title=Development of a fingerprinting panel using medically relevant polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19822020
|Title=Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20157405
|Title=Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population.
|OA=1
}}

{{PMID Auto
|PMID=20222942
|Title=Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke.
|OA=1
}}

{{PMID Auto
|PMID=20565774
|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{PMID Auto
|PMID=21161369
|Title=Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP) gene and breast cancer risk: a meta-analysis.
}}

{{PMID Auto
|PMID=21396799
|Title=Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw.
}}

{{PMID Auto
|PMID=22388798
|Title=Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs243865
|overall_frequency_n=17
|overall_frequency_d=128
|overall_frequency=0.132812
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23257253
|Title=Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in recurrent chronic rhinosinusitis with nasal polyposis
}}

{{PMID Auto
|PMID=23819551
|Title=Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility
}}

{{PMID Auto
|PMID=22710194
|Title=MMP13 polymorphism decreases risk for dental caries.
}}

{{PMID Auto
|PMID=23242659
|Title=Effect of metabolic syndrome risk factors and MMP-2 genetic variations on circulating MMP-2 levels in childhood obesity.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}