{{Rsnum
|rsid=2448490
|Gene=SIPA1
|Chromosome=11
|position=65644564
|Orientation=plus
|GMAF=0.2635
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SIPA1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 10.6 | 47.8 | 41.6
| HCB | 7.3 | 36.5 | 56.2
| JPT | 5.3 | 36.3 | 58.4
| YRI | 3.4 | 24.5 | 72.1
| ASW | 0.0 | 22.8 | 77.2
| CHB | 7.3 | 36.5 | 56.2
| CHD | 5.5 | 37.6 | 56.9
| GIH | 0.0 | 25.7 | 74.3
| LWK | 0.0 | 21.8 | 78.2
| MEX | 6.9 | 41.4 | 51.7
| MKK | 5.1 | 30.8 | 64.1
| TSI | 8.8 | 46.1 | 45.1
| HapMapRevision=28
}}
[[rs2448490]] is a SNP in the signal-induced proliferation-associated 1 [[SIPA1]] gene.

In a study of 1,725 LN=/ER+ [[breast cancer]] patients [[rs2448490]](A;A) homozygotes showed a reduced metastasis risk compared to [[rs2448490]](G) allele carriers. This association was statistically significant for metastasis-free survival (MFS) in multivariate analysis [MFS hazard ratio 0.56, CI: 0.37–0.84, p=0.005) and overall survival (HR 0.59, CI:0.39–0.89, p=0.012)].{{PMID|19825179|OA=1
}}  

This study also found that [[rs2448490]] can be combined with an independent predictor of metastasis free survival, [[rs9306160]], to yield an even stronger prognostic. Specifically, the risk for developing distant metastasis was about 2.5-fold lower (hazard ratio 0.40, CI: 0.24-0.68, p=0.001) for LN-/ER+[[breast cancer]] patients who were [[rs2448490]](A;A) and [[rs9306160]](T) carriers compared to patients who were [[rs2448490]](G) carriers and [[rs9306160]](C;C). {{PMID|19825179|OA=1
}}

{{PMID|19089925|OA=1
}} Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis.

{{PMID Auto
|PMID=23661532
|Title=Sipa1 promoter polymorphism predicts risk and metastasis of lung cancer in Chinese
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}