{{Rsnum
|rsid=2461823
|Gene=NR1I2
|Chromosome=3
|position=119801278
|Orientation=minus
|GMAF=0.3871
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NR1I2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 12.4 | 48.7 | 38.9
| HCB | 18.7 | 38.8 | 42.5
| JPT | 9.7 | 45.1 | 45.1
| YRI | 26.5 | 51.0 | 22.4
| ASW | 27.3 | 50.9 | 21.8
| CHB | 18.7 | 38.8 | 42.5
| CHD | 16.7 | 45.4 | 38.0
| GIH | 19.8 | 41.6 | 38.6
| LWK | 18.2 | 52.7 | 29.1
| MEX | 36.2 | 46.6 | 17.2
| MKK | 16.0 | 48.1 | 35.9
| TSI | 7.8 | 47.1 | 45.1
| HapMapRevision=28
}}{{PMID Auto
|PMID=19940802
|Title=The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease
}}

{{PharmGKB
|RSID=rs2461823
|Name_s=
|Gene_s=NR1I2
|Feature=
|Evidence=PubMed ID:19940802
|Annotation=Risk or phenotype-associated allele: A. Phenotype: The multimarker composed of rs2461823/A-rs7643645/G was significantly associated with severity of nonalcoholic fatty liver disease (NAFLD). Study size: 290. Study population/ethnicity: 188 NAFLD patients with different stages of disease severity and 102 healthy individuals. metric(s): P<6.9x10, beta: 0.45. Type of association: GN.
|Drugs=
|Drug Classes=
|Diseases=Fatty Liver
|Curation Level=Curated
|PharmGKB Accession ID=PA165110550
}}

{{PMID Auto
|PMID=19958310
|Title=The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy
}}

{{PMID Auto
|PMID=18381611
|Title=Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2461823
|overall_frequency_n=72
|overall_frequency_d=128
|overall_frequency=0.5625
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=65
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}