{{Rsnum
|rsid=2472297
|Chromosome=15
|position=74735539
|Orientation=plus
|GMAF=0.1001
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}[[rs2472297]] is a SNP located between the [[CYP1A1]] and [[CYP1A2]] genes on ch 15q24.

A meta-analysis of four GWAS studies of coffee consumption among a total of ~8,000 coffee drinkers of European ancestry found that the [[rs2472297]](T) was strongly associated with increased consumption (p = 5.4 x 10e-14). The estimated effect was an increase of 0.2 cups a day per allele for both this SNP and one other ([[rs6968865]]).{{PMID|21357676|OA=1
}}

{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 55.8 | 38.9 | 5.3
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 84.2 | 15.8 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 95.0 | 5.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 81.0 | 15.5 | 3.4
| MKK | 0.0 | 0.0 | 0.0
| TSI | 83.3 | 15.7 | 1.0
| HapMapRevision=28
}}

{{PMID Auto
|PMID=19479063
|Title=Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
|OA=1
}}

{{PMID Auto
|PMID=20018080
|Title=Effects of covariates and interactions on a genome-wide association analysis of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=21876539
|Title=Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
|OA=1
}}

{{PMID Auto
|PMID=22854411
|Title=Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption
}}

{{PMID Auto
|PMID=23492908
|Title=Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}