{{Rsnum
|rsid=2488457
|Gene=PTPN22
|Chromosome=1
|position=113872746
|Orientation=minus
|GMAF=0.2916
|Gene_s=MIR223,PTPN22
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 7.1 | 29.2 | 63.7
| HCB | 42.3 | 46.7 | 10.9
| JPT | 30.1 | 50.4 | 19.5
| YRI | 0.0 | 0.0 | 100.0
| ASW | 1.8 | 5.3 | 93.0
| CHB | 42.3 | 46.7 | 10.9
| CHD | 44.0 | 47.7 | 8.3
| GIH | 5.9 | 31.7 | 62.4
| LWK | 0.0 | 3.6 | 96.4
| MEX | 13.8 | 41.4 | 44.8
| MKK | 0.0 | 13.5 | 86.5
| TSI | 4.9 | 34.3 | 60.8
| HapMapRevision=28
}}

{{omim
|id=600716
|desc=PROTEIN TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 22; PTPN22
|rsnum=2488457
}}

{{omim
|id=600716
|rsnum=2488457
|variant=0002
}}

{{PMID Auto
|PMID=22197427
|Title=PTPN22 and myasthenia gravis: replication in an Italian population and meta-analysis of literature data
}}

{{PMID|17000021}} No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.

{{PMID|17934143}} Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.

{{PMID|18075792|OA=1
}} PTPN22: its role in SLE and autoimmunity.

{{PMID|18252225|OA=1
}} On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

{{PMID|18578611}} Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population.

{{PMID|19180477|OA=1
}} Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.

{{PMID|19956096|OA=1
}} rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype.

{{PMID|19956101|OA=1
}} Overview of the Rapid Response data.

{{PMID|19956106|OA=1
}} Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

{{PMID|20722033|OA=1
}} The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

{{PMID|21193990}} A PTPN22 promoter polymorphism -1123G>C is associated with RA pathogenesis in Chinese.

{{PMID|22396730|OA=1
}} No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations.

{{PMID Auto
|PMID=23025987
|Title=Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies.
}}

{{PMID Auto
|PMID=23456301
|Title=Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis.
}}

{{PMID Auto
|PMID=25073032
|Title=Association Between a Gain-of-Function Variant of PTPN22 and Rejection in Liver Transplantation
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}