{{Rsnum
|rsid=2500535
|Gene=UST
|Chromosome=6
|position=149008131
|Orientation=plus
|GMAF=0.1368
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=UST
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 6.2 | 93.8
| HCB | 8.0 | 38.0 | 54.0
| JPT | 4.4 | 39.8 | 55.8
| YRI | 0.0 | 12.2 | 87.8
| ASW | 0.0 | 15.8 | 84.2
| CHB | 8.0 | 38.0 | 54.0
| CHD | 7.3 | 36.7 | 56.0
| GIH | 0.0 | 10.9 | 89.1
| LWK | 0.9 | 22.7 | 76.4
| MEX | 6.9 | 48.3 | 44.8
| MKK | 0.6 | 15.4 | 84.0
| TSI | 0.0 | 8.8 | 91.2
| HapMapRevision=28
}}{{PMID|20360315}} [[nortriptyline]] response
{{PMID Auto GWAS
|PMID=20360315
|Trait=Response to antidepressants
|Title=Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project
|RiskAllele=A
|Pval=0.000009
|OR=29.70
|ORtxt=[NR] % worse outcome
}}

{{PharmGKB
|RSID=rs2500535
|Name_s=
|Gene_s=UST
|Feature=
|Evidence=PubMed ID:20360315
|Annotation=Risk or phenotype-associated allele: A Phenotype: The SNP within an intron of the uronyl 2-sulphotransferase gene was associated with outcome at a genome-wide level of significance and with a very small posterior probability of being a false positive. Carriers of the minor A allele experienced less improvement of depression symptoms than carriers of the GG homozygote from week 4 onward. Study size: 312 Study population/ethnicity: Individuals with unipolar depression of at least moderate severity treated with nortriptyline. Type of association: GN
|Drugs=nortriptyline
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165292688
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2500535
|overall_frequency_n=115
|overall_frequency_d=128
|overall_frequency=0.898438
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=99
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|autoscore=1
|webscore=N
|summary_short=May be associated with response to antidepressant treatments.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}