{{Rsnum
|rsid=2504063
|Gene=ESR1
|Chromosome=6
|position=151769572
|Orientation=plus
|GMAF=0.4206
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ESR1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.9 | 46.9 | 37.2
| HCB | 57.4 | 38.2 | 4.4
| JPT | 69.0 | 26.5 | 4.4
| YRI | 41.1 | 48.6 | 10.3
| ASW | 50.9 | 42.1 | 7.0
| CHB | 57.4 | 38.2 | 4.4
| CHD | 67.0 | 28.4 | 4.6
| GIH | 40.6 | 41.6 | 17.8
| LWK | 47.7 | 44.0 | 8.3
| MEX | 32.8 | 46.6 | 20.7
| MKK | 36.1 | 49.7 | 14.2
| TSI | 13.7 | 46.1 | 40.2
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19801982
|Trait=Bone mineral density (spine)
|Title=Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
|RiskAllele=A
|Pval=6E-11
|OR=0.08
|ORtxt=[0.06-0.10] sd decrease
|OA=1
}}

{{PMID Auto
|PMID=19181680
|Title=Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
|OA=1
}}

{{PMID Auto
|PMID=19629617
|Title=Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.
|OA=1
}}

{{PMID Auto
|PMID=20072603
|Title=Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2504063
|overall_frequency_n=52
|overall_frequency_d=128
|overall_frequency=0.40625
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}